Vu CB - Search Results

1

Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.

Vu CB, Corpuz EG, Merry TJ, Pradeepan SG, Bartlett C, Bohacek RS, Botfield MC, Eyermann CJ, Lynch BA, MacNeil IA, Ram MK, van Schravendijk MR, Violette S, Sawyer TK. Vu CB, et al. J Med Chem. 1999 Oct 7;42(20):4088-98. doi: 10.1021/jm990229t. J Med Chem. 1999. PMID: 10514279

2

Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.

Vu CB, Luke GP, Kawahata N, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keenan TP, Pradeepan S, Corpuz E, Merry T, Bohacek RS, Dalgarno DC, Narula SS, van Schravendijk MR, Ram MK, Adams S, Liou S, Keats JA, Violette SM, Guan W, Weigele M, Sawyer TK. Vu CB, et al. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3071-4. doi: 10.1016/s0960-894x(03)00649-8. Bioorg Med Chem Lett. 2003. PMID: 12941336

3

Structure-activity relationships of a novel class of Src SH2 inhibitors.

Buchanan JL, Vu CB, Merry TJ, Corpuz EG, Pradeepan SG, Mani UN, Yang M, Plake HR, Varkhedkar VM, Lynch BA, MacNeil IA, Loiacono KA, Tiong CL, Holt DA. Buchanan JL, et al. Among authors: vu cb. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2359-64. doi: 10.1016/s0960-894x(99)00389-3. Bioorg Med Chem Lett. 1999. PMID: 10476869

4

Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70.

Vu CB, Corpuz EG, Pradeepan SG, Violette S, Bartlett C, Sawyer TK. Vu CB, et al. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3009-14. doi: 10.1016/s0960-894x(99)00524-7. Bioorg Med Chem Lett. 1999. PMID: 10571165

5

Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.

Sundaramoorthi R, Siedem C, Vu CB, Dalgarno DC, Laird EC, Botfield MC, Combs AB, Adams SE, Yuan RW, Weigele M, Narula SS. Sundaramoorthi R, et al. Among authors: vu cb. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1665-9. doi: 10.1016/s0960-894x(01)00269-4. Bioorg Med Chem Lett. 2001. PMID: 11425533

6

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.

Shakespeare W, Yang M, Bohacek R, Cerasoli F, Stebbins K, Sundaramoorthi R, Azimioara M, Vu C, Pradeepan S, Metcalf C 3rd, Haraldson C, Merry T, Dalgarno D, Narula S, Hatada M, Lu X, van Schravendijk MR, Adams S, Violette S, Smith J, Guan W, Bartlett C, Herson J, Iuliucci J, Weigele M, Sawyer T. Shakespeare W, et al. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9373-8. doi: 10.1073/pnas.97.17.9373. Proc Natl Acad Sci U S A. 2000. PMID: 10944210 Free PMC article.

7

Recent advances in the design and synthesis of SH2 inhibitors of Src, Grb2 and ZAP-70.

Vu CB. Vu CB. Curr Med Chem. 2000 Oct;7(10):1081-100. doi: 10.2174/0929867003374390. Curr Med Chem. 2000. PMID: 10911019 Review.

8

Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.

Vu CB, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Chen L, Zhang J, Petter RC. Vu CB, et al. J Med Chem. 2004 Aug 12;47(17):4291-9. doi: 10.1021/jm0498405. J Med Chem. 2004. PMID: 15294001

9

Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.

Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC. Peng H, et al. Among authors: vu cb. J Med Chem. 2004 Dec 2;47(25):6218-29. doi: 10.1021/jm0494321. J Med Chem. 2004. PMID: 15566292

10

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB. Vu CB, et al. J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954. J Med Chem. 2009. PMID: 19199480

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