Maegawa H - Search Results

1

Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance.

Maegawa H, Hasegawa M, Sugai S, Obata T, Ugi S, Morino K, Egawa K, Fujita T, Sakamoto T, Nishio Y, Kojima H, Haneda M, Yasuda H, Kikkawa R, Kashiwagi A. Maegawa H, et al. J Biol Chem. 1999 Oct 15;274(42):30236-43. doi: 10.1074/jbc.274.42.30236. J Biol Chem. 1999. PMID: 10514516 Free article.

2

Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.

Maegawa H, Ide R, Hasegawa M, Ugi S, Egawa K, Iwanishi M, Kikkawa R, Shigeta Y, Kashiwagi A. Maegawa H, et al. J Biol Chem. 1995 Mar 31;270(13):7724-30. doi: 10.1074/jbc.270.13.7724. J Biol Chem. 1995. PMID: 7535776 Free article.

Both protein kinase C activities and phorbol dibutyrate binding to intact cells were unchanged; however, cytosolic protein-tyrosine phosphatase (PTPase) activity increased within 1 h prior to the impairment of insulin receptor kinase in HG cells (Maegawa, H., …

Both protein kinase C activities and phorbol dibutyrate binding to intact cells were unchanged; however, cytosolic protein-tyrosine phosphat …

3

[Obesity as a risk factor for developing non-insulin dependent diabetes mellitus--obesity and insulin resistance].

Maegawa H, Kashiwagi A, Shigeta Y. Maegawa H, et al. Nihon Naibunpi Gakkai Zasshi. 1995 Mar 20;71(2):97-104. doi: 10.1507/endocrine1927.71.2_97. Nihon Naibunpi Gakkai Zasshi. 1995. PMID: 7750630 Review. Japanese.

4

Expression of dominant negative mutant SHPTP2 attenuates phosphatidylinositol 3'-kinase activity via modulation of phosphorylation of insulin receptor substrate-1.

Ugi S, Maegawa H, Kashiwagi A, Adachi M, Olefsky JM, Kikkawa R. Ugi S, et al. Among authors: maegawa h. J Biol Chem. 1996 May 24;271(21):12595-602. doi: 10.1074/jbc.271.21.12595. J Biol Chem. 1996. PMID: 8647870 Free article.

5

SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates.

Maegawa H, Kashiwagi A, Fujita T, Ugi S, Hasegawa M, Obata T, Nishio Y, Kojima H, Hidaka H, Kikkawa R. Maegawa H, et al. Biochem Biophys Res Commun. 1996 Nov 1;228(1):122-7. doi: 10.1006/bbrc.1996.1626. Biochem Biophys Res Commun. 1996. PMID: 8912646

6

Insulin signaling and its regulation of system A amino acid uptake in cultured rat vascular smooth muscle cells.

Obata T, Kashiwagi A, Maegawa H, Nishio Y, Ugi S, Hidaka H, Kikkawa R. Obata T, et al. Among authors: maegawa h. Circ Res. 1996 Dec;79(6):1167-76. doi: 10.1161/01.res.79.6.1167. Circ Res. 1996. PMID: 8943955

7

Protein tyrosine phosphatases as stimulators and inhibitors of insulin signalling: possible candidates for insulin resistance.

Kashiwagi A, Maegawa H, Kikkawa R. Kashiwagi A, et al. Among authors: maegawa h. Jpn J Physiol. 1997;47 Suppl 1:S35-6. Jpn J Physiol. 1997. PMID: 9266322 No abstract available.

8

High glucose-induced abnormal epidermal growth factor signaling.

Obata T, Maegawa H, Kashiwagi A, Pillay TS, Kikkawa R. Obata T, et al. Among authors: maegawa h. J Biochem. 1998 May;123(5):813-20. doi: 10.1093/oxfordjournals.jbchem.a022009. J Biochem. 1998. PMID: 9562610 Free article.

We have reported that high glucose conditions (27 mM for 4 days) induces activation of protein tyrosine phosphatases (PTPases) which are associated with impaired insulin signaling in Rat 1 fibroblasts expressing human insulin receptors [Maegawa, H. et al. (1995) J. …

We have reported that high glucose conditions (27 mM for 4 days) induces activation of protein tyrosine phosphatases (PTPases) which are ass …

9

Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I.

Fujita T, Maegawa H, Kashiwagi A, Hirai H, Kikkawa R. Fujita T, et al. Among authors: maegawa h. J Biochem. 1998 Dec 1;124(6):1111-6. doi: 10.1093/oxfordjournals.jbchem.a022228. J Biochem. 1998. PMID: 9832615 Free article.

10

A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle.

Maegawa H, Obata T, Shibata T, Fujita T, Ugi S, Morino K, Nishio Y, Kojima H, Hidaka H, Haneda M, Yasuda H, Kikkawa R, Kashiwagi A. Maegawa H, et al. Diabetologia. 1999 Feb;42(2):151-9. doi: 10.1007/s001250051133. Diabetologia. 1999. PMID: 10064094

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