Himes RH - Search Results

1

Conformationally restricted paclitaxel analogues: macrocyclic mimics of the "hydrophobic collapse" conformation.

Boge TC, Wu ZJ, Himes RH, Vander Velde DG, Georg GI. Boge TC, et al. Among authors: himes rh. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3047-52. doi: 10.1016/s0960-894x(99)00522-3. Bioorg Med Chem Lett. 1999. PMID: 10571173

2

A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach.

Liu Y, Ali SM, Boge TC, Georg GI, Victory S, Zygmunt J, Marquez RT, Himes RH. Liu Y, et al. Among authors: himes rh. Comb Chem High Throughput Screen. 2002 Feb;5(1):39-48. doi: 10.2174/1386207023330615. Comb Chem High Throughput Screen. 2002. PMID: 11860338

3

Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24.

Vidya R, Eggen M, Georg GI, Himes RH. Vidya R, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2003 Feb 24;13(4):757-60. doi: 10.1016/s0960-894x(02)01023-5. Bioorg Med Chem Lett. 2003. PMID: 12639575

4

Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI. Buck SB, et al. Among authors: himes rh. J Med Chem. 2004 Jan 29;47(3):696-702. doi: 10.1021/jm030278c. J Med Chem. 2004. PMID: 14736249

5

Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI. Buck SB, et al. Among authors: himes rh. J Med Chem. 2004 Jul 1;47(14):3697-9. doi: 10.1021/jm030555f. J Med Chem. 2004. PMID: 15214797

6

Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe.

Spletstoser JT, Flaherty PT, Himes RH, Georg GI. Spletstoser JT, et al. Among authors: himes rh. J Med Chem. 2004 Dec 16;47(26):6459-65. doi: 10.1021/jm030581d. J Med Chem. 2004. PMID: 15588080

7

Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ.

Rice A, Liu Y, Michaelis ML, Himes RH, Georg GI, Audus KL. Rice A, et al. Among authors: himes rh. J Med Chem. 2005 Feb 10;48(3):832-8. doi: 10.1021/jm040114b. J Med Chem. 2005. PMID: 15689167

8

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells.

Ge H, Vasandani V, Huff JK, Audus KL, Himes RH, Seelig A, Georg GI. Ge H, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2006 Jan 15;16(2):433-6. doi: 10.1016/j.bmcl.2005.09.043. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16271474

9

Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells.

Spletstoser JT, Turunen BJ, Desino K, Rice A, Datta A, Dutta D, Huff JK, Himes RH, Audus KL, Seelig A, Georg GI. Spletstoser JT, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2006 Feb;16(3):495-8. doi: 10.1016/j.bmcl.2005.10.063. Epub 2005 Nov 10. Bioorg Med Chem Lett. 2006. PMID: 16289636

10

Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones.

Kimball FS, Tunoori AR, Victory SF, Dutta D, White JM, Himes RH, Georg GI. Kimball FS, et al. Among authors: himes rh. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4703-7. doi: 10.1016/j.bmcl.2007.05.103. Epub 2007 Jun 13. Bioorg Med Chem Lett. 2007. PMID: 17614274 Free PMC article.

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