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Page 1
Fused bicyclic Gly-Asp beta-turn mimics with specific affinity for GPIIb-IIIa.
Fisher MJ, Arfstan AE, Giese U, Gunn BP, Harms CS, Khau V, Kinnick MD, Lindstrom TD, Martinelli MJ, Mest HJ, Mohr M, Morin JM Jr, Mullaney JT, Nunes A, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Sommer B, Stenzel W, Towner RD, Um SL, et al. Fisher MJ, et al. Among authors: ruterbories kj. J Med Chem. 1999 Nov 18;42(23):4875-89. doi: 10.1021/jm990365y. J Med Chem. 1999. PMID: 10579850
Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.
Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM. Su T, et al. Among authors: ruterbories kj. J Med Chem. 1997 Dec 19;40(26):4308-18. doi: 10.1021/jm9704863. J Med Chem. 1997. PMID: 9435900
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere.
Fisher MJ, Giese U, Harms CS, Kinnick MD, Lindstrom TD, McCowan JR, Mest HJ, Morin JM Jr, Mullaney JT, Paal M, Rapp A, Rühter G, Ruterbories KJ, Sall DJ, Scarborough RM, Schotten T, Stenzel W, Towner RD, Um SL, Utterback BG, Wyss VL, Jakubowski JA. Fisher MJ, et al. Among authors: ruterbories kj. Bioorg Med Chem Lett. 2000 Feb 21;10(4):385-9. doi: 10.1016/s0960-894x(00)00008-1. Bioorg Med Chem Lett. 2000. PMID: 10714506
Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [(13) C8 ]-evacetrapib as a tracer.
Cannady EA, Aburub A, Ward C, Hinds C, Czeskis B, Ruterbories K, Suico JG, Royalty J, Ortega D, Pack BW, Begum SL, Annes WF, Lin Q, Small DS. Cannady EA, et al. J Labelled Comp Radiopharm. 2016 May 30;59(6):238-44. doi: 10.1002/jlcr.3358. Epub 2015 Dec 7. J Labelled Comp Radiopharm. 2016. PMID: 26639670 Free PMC article. Clinical Trial.
34 results