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[No title available]
[No authors listed] [No authors listed] PMID: 33509583
Characterization of binding mode of action of a blocking anti-platelet-derived growth factor (PDGF)-B monoclonal antibody, MOR8457, reveals conformational flexibility and avidity needed for PDGF-BB to bind PDGF receptor-β.
Kuai J, Mosyak L, Brooks J, Cain M, Carven GJ, Ogawa S, Ishino T, Tam M, Lavallie ER, Yang Z, Ponsel D, Rauchenberger R, Arch R, Pullen N. Kuai J, et al. Among authors: carven gj. Biochemistry. 2015 Mar 17;54(10):1918-29. doi: 10.1021/bi5015425. Epub 2015 Mar 6. Biochemistry. 2015. PMID: 25707433
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.
Apgar JR, Tam ASP, Sorm R, Moesta S, King AC, Yang H, Kelleher K, Murphy D, D'Antona AM, Yan G, Zhong X, Rodriguez L, Ma W, Ferguson DE, Carven GJ, Bennett EM, Lin L. Apgar JR, et al. Among authors: carven gj. PLoS One. 2020 May 7;15(5):e0232713. doi: 10.1371/journal.pone.0232713. eCollection 2020. PLoS One. 2020. PMID: 32379792 Free PMC article.
Blocking extracellular activation of myostatin as a strategy for treating muscle wasting.
Pirruccello-Straub M, Jackson J, Wawersik S, Webster MT, Salta L, Long K, McConaughy W, Capili A, Boston C, Carven GJ, Mahanthappa NK, Turner KJ, Donovan A. Pirruccello-Straub M, et al. Among authors: carven gj. Sci Rep. 2018 Feb 2;8(1):2292. doi: 10.1038/s41598-018-20524-9. Sci Rep. 2018. PMID: 29396542 Free PMC article.
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