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Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite.
Nienaber VL, Davidson D, Edalji R, Giranda VL, Klinghofer V, Henkin J, Magdalinos P, Mantei R, Merrick S, Severin JM, Smith RA, Stewart K, Walter K, Wang J, Wendt M, Weitzberg M, Zhao X, Rockway T. Nienaber VL, et al. Among authors: wang j. Structure. 2000 May 15;8(5):553-63. doi: 10.1016/s0969-2126(00)00136-2. Structure. 2000. PMID: 10801494 Free article.
Soluble human urokinase receptor is composed of two active units.
Higazi AA, Mazar A, Wang J, Quan N, Griffin R, Reilly R, Henkin J, Cines DB. Higazi AA, et al. Among authors: wang j. J Biol Chem. 1997 Feb 21;272(8):5348-53. doi: 10.1074/jbc.272.8.5348. J Biol Chem. 1997. PMID: 9030610 Free article.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Sheppard GS, Wang J, Kawai M, Fidanze SD, BaMaung NY, Erickson SA, Barnes DM, Tedrow JS, Kolaczkowski L, Vasudevan A, Park DC, Wang GT, Sanders WJ, Mantei RA, Palazzo F, Tucker-Garcia L, Lou P, Zhang Q, Park CH, Kim KH, Petros A, Olejniczak E, Nettesheim D, Hajduk P, Henkin J, Lesniewski R, Davidsen SK, Bell RL. Sheppard GS, et al. Among authors: wang gt, wang j. J Med Chem. 2006 Jun 29;49(13):3832-49. doi: 10.1021/jm0601001. J Med Chem. 2006. PMID: 16789740
Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.
Kawai M, BaMaung NY, Fidanze SD, Erickson SA, Tedrow JS, Sanders WJ, Vasudevan A, Park C, Hutchins C, Comess KM, Kalvin D, Wang J, Zhang Q, Lou P, Tucker-Garcia L, Bouska J, Bell RL, Lesniewski R, Henkin J, Sheppard GS. Kawai M, et al. Among authors: wang j. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. doi: 10.1016/j.bmcl.2006.03.085. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16632353
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