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Page 1
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Butera JA, Antane MM, Antane SA, Argentieri TM, Freeden C, Graceffa RF, Hirth BH, Jenkins D, Lennox JR, Matelan E, Norton NW, Quagliato D, Sheldon JH, Spinelli W, Warga D, Wojdan A, Woods M. Butera JA, et al. Among authors: matelan e. J Med Chem. 2000 Mar 23;43(6):1187-202. doi: 10.1021/jm9905099. J Med Chem. 2000. PMID: 10737752
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.
Steffan RJ, Matelan E, Ashwell MA, Moore WJ, Solvibile WR, Trybulski E, Chadwick CC, Chippari S, Kenney T, Eckert A, Borges-Marcucci L, Keith JC, Xu Z, Mosyak L, Harnish DC. Steffan RJ, et al. Among authors: matelan e. J Med Chem. 2004 Dec 16;47(26):6435-8. doi: 10.1021/jm049194+. J Med Chem. 2004. PMID: 15588074
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Wrobel J, Steffan R, Bowen SM, Magolda R, Matelan E, Unwalla R, Basso M, Clerin V, Gardell SJ, Nambi P, Quinet E, Reminick JI, Vlasuk GP, Wang S, Feingold I, Huselton C, Bonn T, Farnegardh M, Hansson T, Nilsson AG, Wilhelmsson A, Zamaratski E, Evans MJ. Wrobel J, et al. Among authors: matelan e. J Med Chem. 2008 Nov 27;51(22):7161-8. doi: 10.1021/jm800799q. J Med Chem. 2008. PMID: 18973288
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.
Singhaus RR, Bernotas RC, Steffan R, Matelan E, Quinet E, Nambi P, Feingold I, Huselton C, Wilhelmsson A, Goos-Nilsson A, Wrobel J. Singhaus RR, et al. Among authors: matelan e. Bioorg Med Chem Lett. 2010 Jan 15;20(2):521-5. doi: 10.1016/j.bmcl.2009.11.098. Epub 2009 Nov 23. Bioorg Med Chem Lett. 2010. PMID: 20005711
Control of chronic inflammation with pathway selective estrogen receptor ligands.
Steffan RJ, Matelan E, Ashwell MA, Moore WJ, Solvibile WR, Trybulski E, Chadwick CC, Chippari S, Kenney T, Winneker RC, Eckert A, Borges-Marcucci L, Adelman SJ, Xu Z, Mosyak L, Harnish DC. Steffan RJ, et al. Among authors: matelan e. Curr Top Med Chem. 2006;6(2):103-11. doi: 10.2174/156802606775270279. Curr Top Med Chem. 2006. PMID: 16454762 Review.
Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.
Chadwick CC, Chippari S, Matelan E, Borges-Marcucci L, Eckert AM, Keith JC Jr, Albert LM, Leathurby Y, Harris HA, Bhat RA, Ashwell M, Trybulski E, Winneker RC, Adelman SJ, Steffan RJ, Harnish DC. Chadwick CC, et al. Among authors: matelan e. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2543-8. doi: 10.1073/pnas.0405841102. Epub 2005 Feb 7. Proc Natl Acad Sci U S A. 2005. PMID: 15699342 Free PMC article.