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Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Butera JA, Antane MM, Antane SA, Argentieri TM, Freeden C, Graceffa RF, Hirth BH, Jenkins D, Lennox JR, Matelan E, Norton NW, Quagliato D, Sheldon JH, Spinelli W, Warga D, Wojdan A, Woods M. Butera JA, et al. Among authors: warga d. J Med Chem. 2000 Mar 23;43(6):1187-202. doi: 10.1021/jm9905099. J Med Chem. 2000. PMID: 10737752
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones.
Gilbert AM, Antane MM, Argentieri TM, Butera JA, Francisco GD, Freeden C, Gundersen EG, Graceffa RF, Herbst D, Hirth BH, Lennox JR, McFarlane G, Norton NW, Quagliato D, Sheldon JH, Warga D, Wojdan A, Woods M. Gilbert AM, et al. Among authors: warga d. J Med Chem. 2000 Mar 23;43(6):1203-14. doi: 10.1021/jm9905108. J Med Chem. 2000. PMID: 10737753