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Page 1
Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP).
Barlow HC, Bowman KJ, Curtin NJ, Calvert AH, Golding BT, Huang B, Loughlin PJ, Newell DR, Smith PG, Griffin RJ. Barlow HC, et al. Among authors: griffin rj. Bioorg Med Chem Lett. 2000 Mar 20;10(6):585-9. doi: 10.1016/s0960-894x(00)00053-6. Bioorg Med Chem Lett. 2000. PMID: 10741559
4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.
Mesguiche V, Parsons RJ, Arris CE, Bentley J, Boyle FT, Curtin NJ, Davies TG, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury P, Johnson LN, Newell DR, Noble ME, Wang LZ, Hardcastle IR. Mesguiche V, et al. Among authors: griffin rj. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22. doi: 10.1016/s0960-894x(02)00884-3. Bioorg Med Chem Lett. 2003. PMID: 12482427
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
Sayle KL, Bentley J, Boyle FT, Calvert AH, Cheng Y, Curtin NJ, Endicott JA, Golding BT, Hardcastle IR, Jewsbury P, Mesguiche V, Newell DR, Noble ME, Parsons RJ, Pratt DJ, Wang LZ, Griffin RJ. Sayle KL, et al. Among authors: griffin rj. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3079-82. doi: 10.1016/s0960-894x(03)00651-6. Bioorg Med Chem Lett. 2003. PMID: 12941338
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
Hardcastle IR, Arris CE, Bentley J, Boyle FT, Chen Y, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury P, Menyerol J, Mesguiche V, Newell DR, Noble ME, Pratt DJ, Wang LZ, Whitfield HJ. Hardcastle IR, et al. Among authors: griffin rj. J Med Chem. 2004 Jul 15;47(15):3710-22. doi: 10.1021/jm0311442. J Med Chem. 2004. PMID: 15239650
Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha1-acid glycoprotein.
Curtin NJ, Barlow HC, Bowman KJ, Calvert AH, Davison R, Golding BT, Huang B, Loughlin PJ, Newell DR, Smith PG, Griffin RJ. Curtin NJ, et al. Among authors: griffin rj. J Med Chem. 2004 Sep 23;47(20):4905-22. doi: 10.1021/jm040772w. J Med Chem. 2004. PMID: 15369395
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction.
Hardcastle IR, Ahmed SU, Atkins H, Calvert AH, Curtin NJ, Farnie G, Golding BT, Griffin RJ, Guyenne S, Hutton C, Källblad P, Kemp SJ, Kitching MS, Newell DR, Norbedo S, Northen JS, Reid RJ, Saravanan K, Willems HM, Lunec J. Hardcastle IR, et al. Among authors: griffin rj. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1515-20. doi: 10.1016/j.bmcl.2004.12.061. Bioorg Med Chem Lett. 2005. PMID: 15713419
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK).
Desage-El Murr M, Cano C, Golding BT, Hardcastle IR, Hummersome M, Frigerio M, Curtin NJ, Menear K, Richardson C, Smith GC, Griffin RJ. Desage-El Murr M, et al. Among authors: griffin rj. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4885-90. doi: 10.1016/j.bmcl.2008.07.066. Epub 2008 Jul 20. Bioorg Med Chem Lett. 2008. PMID: 18678488
359 results