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Regulatable promoters for use in gene therapy applications: modification of the 5'-flanking region of the CFTR gene with multiple cAMP response elements to support basal, low-level gene expression that can be upregulated by exogenous agents that raise intracellular levels of cAMP.
Suzuki M, Singh RN, Crystal RG. Suzuki M, et al. Among authors: singh rn. Hum Gene Ther. 1996 Oct 1;7(15):1883-93. doi: 10.1089/hum.1996.7.15-1883. Hum Gene Ther. 1996. PMID: 8894680
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG. Kaner RJ, et al. Among authors: singh r. Am J Respir Cell Mol Biol. 1999 Mar;20(3):361-70. doi: 10.1165/ajrcmb.20.3.3398. Am J Respir Cell Mol Biol. 1999. PMID: 10030833
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