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Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function.
Marathe S, Miranda SR, Devlin C, Johns A, Kuriakose G, Williams KJ, Schuchman EH, Tabas I. Marathe S, et al. Hum Mol Genet. 2000 Aug 12;9(13):1967-76. doi: 10.1093/hmg/9.13.1967. Hum Mol Genet. 2000. PMID: 10942425
Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis.
Tabas I, Marathe S, Keesler GA, Beatini N, Shiratori Y. Tabas I, et al. Among authors: marathe s. J Biol Chem. 1996 Sep 13;271(37):22773-81. doi: 10.1074/jbc.271.37.22773. J Biol Chem. 1996. PMID: 8798453 Free article.
251 results