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Human neutrophil elastase proteolytically activates the platelet integrin alphaIIbbeta3 through cleavage of the carboxyl terminus of the alphaIIb subunit heavy chain. Involvement in the potentiation of platelet aggregation.
Si-Tahar M, Pidard D, Balloy V, Moniatte M, Kieffer N, Van Dorsselaer A, Chignard M. Si-Tahar M, et al. Among authors: chignard m. J Biol Chem. 1997 Apr 25;272(17):11636-47. doi: 10.1074/jbc.272.17.11636. J Biol Chem. 1997. PMID: 9111081 Free article.
We previously demonstrated that while NE by itself does not activate human platelets, it strongly enhances the weak aggregation induced by a threshold concentration of cathepsin G (threshold of cathepsin G) (Renesto, P., and Chignard, M. (1993) Blood 82, 139-144). T …
We previously demonstrated that while NE by itself does not activate human platelets, it strongly enhances the weak aggregation induced by a …
Phosphoinositide 3-kinase inhibition reverses platelet aggregation triggered by the combination of the neutrophil proteinases elastase and cathepsin G without impairing alpha(IIb)beta(3) integrin activation.
Trumel C, Si-Tahar M, Balloy V, Chignard M, Chap H, Payrastre B, Plantavid M, Pidard D. Trumel C, et al. Among authors: chignard m. FEBS Lett. 2000 Nov 10;484(3):184-8. doi: 10.1016/s0014-5793(00)02152-9. FEBS Lett. 2000. PMID: 11078875 Free article.
Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4.
Valenzuela-Fernández A, Planchenault T, Baleux F, Staropoli I, Le-Barillec K, Leduc D, Delaunay T, Lazarini F, Virelizier JL, Chignard M, Pidard D, Arenzana-Seisdedos F. Valenzuela-Fernández A, et al. Among authors: chignard m. J Biol Chem. 2002 May 3;277(18):15677-89. doi: 10.1074/jbc.M111388200. Epub 2002 Feb 26. J Biol Chem. 2002. PMID: 11867624 Free article.
178 results