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Dysregulation of protein synthesis and disease.
Le Quesne JP, Spriggs KA, Bushell M, Willis AE. Le Quesne JP, et al. J Pathol. 2010 Jan;220(2):140-51. doi: 10.1002/path.2627. J Pathol. 2010. PMID: 19827082 Review.
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JD, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ. Knight JRP, et al. Cancer Discov. 2021 May;11(5):1228-1247. doi: 10.1158/2159-8290.CD-20-0652. Epub 2020 Dec 16. Cancer Discov. 2021. PMID: 33328217 Free PMC article.
Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).
Chernova T, Murphy FA, Galavotti S, Sun XM, Powley IR, Grosso S, Schinwald A, Zacarias-Cabeza J, Dudek KM, Dinsdale D, Le Quesne J, Bennett J, Nakas A, Greaves P, Poland CA, Donaldson K, Bushell M, Willis AE, MacFarlane M. Chernova T, et al. Curr Biol. 2017 Nov 6;27(21):3302-3314.e6. doi: 10.1016/j.cub.2017.09.007. Curr Biol. 2017. PMID: 29112861 Free PMC article.
The pathogenesis of mesothelioma is driven by a dysregulated translatome.
Grosso S, Marini A, Gyuraszova K, Voorde JV, Sfakianos A, Garland GD, Tenor AR, Mordue R, Chernova T, Morone N, Sereno M, Smith CP, Officer L, Farahmand P, Rooney C, Sumpton D, Das M, Teodósio A, Ficken C, Martin MG, Spriggs RV, Sun XM, Bushell M, Sansom OJ, Murphy D, MacFarlane M, Le Quesne JPC, Willis AE. Grosso S, et al. Nat Commun. 2021 Aug 13;12(1):4920. doi: 10.1038/s41467-021-25173-7. Nat Commun. 2021. PMID: 34389715 Free PMC article.
Resistance to HSP90 inhibition involving loss of MCL1 addiction.
Busacca S, Law EW, Powley IR, Proia DA, Sequeira M, Le Quesne J, Klabatsa A, Edwards JM, Matchett KB, Luo JL, Pringle JH, El-Tanani M, MacFarlane M, Fennell DA. Busacca S, et al. Oncogene. 2016 Mar 24;35(12):1483-92. doi: 10.1038/onc.2015.213. Epub 2015 Jun 22. Oncogene. 2016. PMID: 26096930 Free PMC article.
75 results