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Page 1
The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.
Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR Jr, Dantzman CL, Edwards PD, Jacobs RT, Mauger RC, Murphy MM, Palmer W, Pine KK, Rumsey WL, Garcia-Davenport LE, Shaw A, Steelman GB, Surian JM, Vacek EP. Veale CA, et al. Among authors: edwards pd. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52. doi: 10.1016/s0960-894x(00)00387-5. Bioorg Med Chem Lett. 2000. PMID: 10987424
Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
Bernstein PR, Andisik D, Bradley PK, Bryant CB, Ceccarelli C, Damewood JR Jr, Earley R, Edwards PD, Feeney S, Gomes BC, et al. Bernstein PR, et al. Among authors: edwards pd. J Med Chem. 1994 Sep 30;37(20):3313-26. doi: 10.1021/jm00046a016. J Med Chem. 1994. PMID: 7932559
Design of orally active, non-peptidic inhibitors of human leukocyte elastase.
Brown FJ, Andisik DW, Bernstein PR, Bryant CB, Ceccarelli C, Damewood JR Jr, Edwards PD, Earley RA, Feeney S, Green RC, et al. Brown FJ, et al. Among authors: edwards pd. J Med Chem. 1994 Apr 29;37(9):1259-61. doi: 10.1021/jm00035a004. J Med Chem. 1994. PMID: 8176703 No abstract available.
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.
Veale CA, Bernstein PR, Bohnert CM, Brown FJ, Bryant C, Damewood JR Jr, Earley R, Feeney SW, Edwards PD, Gomes B, Hulsizer JM, Kosmider BJ, Krell RD, Moore G, Salcedo TW, Shaw A, Silberstein DS, Steelman GB, Stein M, Strimpler A, Thomas RM, Vacek EP, Williams JC, Wolanin DJ, Woolson S. Veale CA, et al. Among authors: edwards pd. J Med Chem. 1997 Sep 26;40(20):3173-81. doi: 10.1021/jm970250z. J Med Chem. 1997. PMID: 9379436
Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.
Brown DG, Bernstein PR, Griffin A, Wesolowski S, Labrecque D, Tremblay MC, Sylvester M, Mauger R, Edwards PD, Throner SR, Folmer JJ, Cacciola J, Scott C, Lazor LA, Pourashraf M, Santhakumar V, Potts WM, Sydserff S, Giguère P, Lévesque C, Dasser M, Groblewski T. Brown DG, et al. Among authors: edwards pd. J Med Chem. 2014 Feb 13;57(3):733-58. doi: 10.1021/jm4014828. Epub 2014 Jan 27. J Med Chem. 2014. PMID: 24410637
86 results