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Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.
Wartmann T, Mayerle J, Kähne T, Sahin-Tóth M, Ruthenbürger M, Matthias R, Kruse A, Reinheckel T, Peters C, Weiss FU, Sendler M, Lippert H, Schulz HU, Aghdassi A, Dummer A, Teller S, Halangk W, Lerch MM. Wartmann T, et al. Among authors: reinheckel t. Gastroenterology. 2010 Feb;138(2):726-37. doi: 10.1053/j.gastro.2009.10.048. Epub 2009 Nov 10. Gastroenterology. 2010. PMID: 19900452 Free PMC article.
Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice.
Malla SR, Krueger B, Wartmann T, Sendler M, Mahajan UM, Weiss FU, Thiel FG, De Boni C, Gorelick FS, Halangk W, Aghdassi AA, Reinheckel T, Gukovskaya AS, Lerch MM, Mayerle J. Malla SR, et al. Among authors: reinheckel t. Cell Mol Life Sci. 2020 May;77(9):1811-1825. doi: 10.1007/s00018-019-03254-7. Epub 2019 Jul 30. Cell Mol Life Sci. 2020. PMID: 31363815 Free PMC article.
Thyroid functions of mouse cathepsins B, K, and L.
Friedrichs B, Tepel C, Reinheckel T, Deussing J, von Figura K, Herzog V, Peters C, Saftig P, Brix K. Friedrichs B, et al. Among authors: reinheckel t. J Clin Invest. 2003 Jun;111(11):1733-45. doi: 10.1172/JCI15990. J Clin Invest. 2003. PMID: 12782676 Free PMC article.
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice.
Bühling F, Kouadio M, Chwieralski CE, Kern U, Hohlfeld JM, Klemm N, Friedrichs N, Roth W, Deussing JM, Peters C, Reinheckel T. Bühling F, et al. Among authors: reinheckel t. PLoS One. 2011;6(10):e26247. doi: 10.1371/journal.pone.0026247. Epub 2011 Oct 12. PLoS One. 2011. PMID: 22022579 Free PMC article.
Legumain is activated in macrophages during pancreatitis.
Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, Storz P, Halangk W, Bogyo M, Bunnett NW. Edgington-Mitchell LE, et al. Among authors: reinheckel t. Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G548-60. doi: 10.1152/ajpgi.00047.2016. Epub 2016 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27514475 Free PMC article.
185 results