A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens.
Mattson NM, Chan AKN, Miyashita K, Mukhaleva E, Chang WH, Yang L, Ma N, Wang Y, Pokharel SP, Li M, Liu Q, Xu X, Chen R, Singh P, Zhang L, Elsayed Z, Chen B, Keen D, Pirrotte P, Rosen ST, Chen J, LaBarge MA, Shively JE, Vaidehi N, Rockne RC, Feng M, Chen CW.
Mattson NM, et al. Among authors: vaidehi n.
Nat Struct Mol Biol. 2024 Mar;31(3):465-475. doi: 10.1038/s41594-024-01211-y. Epub 2024 Feb 5.
Nat Struct Mol Biol. 2024.
PMID: 38316881
Free PMC article.