Losey HC - Search Results

1

Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.

Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD. Chen H, et al. Among authors: losey hc. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11942-7. doi: 10.1073/pnas.210395097. Proc Natl Acad Sci U S A. 2000. PMID: 11035791 Free PMC article.

2

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway.

Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM. Mulichak AM, et al. Among authors: losey hc. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9238-43. doi: 10.1073/pnas.1233577100. Epub 2003 Jul 21. Proc Natl Acad Sci U S A. 2003. PMID: 12874381 Free PMC article.

3

Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway.

Merkel AB, Temple GK, Burkart MD, Losey HC, Beis K, Walsh CT, Naismith JH. Merkel AB, et al. Among authors: losey hc. Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1226-8. doi: 10.1107/s0907444902007382. Epub 2002 Jun 20. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 12077451

4

The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates.

Ehmann DE, Shaw-Reid CA, Losey HC, Walsh CT. Ehmann DE, et al. Among authors: losey hc. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2509-14. doi: 10.1073/pnas.040572897. Proc Natl Acad Sci U S A. 2000. PMID: 10688898 Free PMC article.

5

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT. Losey HC, et al. Biochemistry. 2001 Apr 17;40(15):4745-55. doi: 10.1021/bi010050w. Biochemistry. 2001. PMID: 11294642

6

Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.

Mulichak AM, Losey HC, Walsh CT, Garavito RM. Mulichak AM, et al. Among authors: losey hc. Structure. 2001 Jul 3;9(7):547-57. doi: 10.1016/s0969-2126(01)00616-5. Structure. 2001. PMID: 11470430 Free article.

7

Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.

Walsh CT, Chen H, Keating TA, Hubbard BK, Losey HC, Luo L, Marshall CG, Miller DA, Patel HM. Walsh CT, et al. Among authors: losey hc. Curr Opin Chem Biol. 2001 Oct;5(5):525-34. doi: 10.1016/s1367-5931(00)00235-0. Curr Opin Chem Biol. 2001. PMID: 11578925 Review.

8

Antibiotic glycosyltransferases.

Walsh CT, Losey HC, Freel Meyers CL. Walsh CT, et al. Among authors: losey hc. Biochem Soc Trans. 2003 Jun;31(Pt 3):487-92. doi: 10.1042/bst0310487. Biochem Soc Trans. 2003. PMID: 12773141 Review.

9

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides.

Losey HC, Jiang J, Biggins JB, Oberthür M, Ye XY, Dong SD, Kahne D, Thorson JS, Walsh CT. Losey HC, et al. Chem Biol. 2002 Dec;9(12):1305-14. doi: 10.1016/s1074-5521(02)00270-3. Chem Biol. 2002. PMID: 12498883

10

Antibiotic glycosyltransferases: antibiotic maturation and prospects for reprogramming.

Walsh C, Freel Meyers CL, Losey HC. Walsh C, et al. Among authors: losey hc. J Med Chem. 2003 Jul 31;46(16):3425-36. doi: 10.1021/jm030257i. J Med Chem. 2003. PMID: 12877577 Review. No abstract available.

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