Edwards PD - Search Results

1

Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases.

Edwards PD, Mauger RC, Cottrell KM, Morris FX, Pine KK, Sylvester MA, Scott CW, Furlong ST. Edwards PD, et al. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2291-4. doi: 10.1016/s0960-894x(00)00460-1. Bioorg Med Chem Lett. 2000. PMID: 11055341

2

The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.

Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR Jr, Dantzman CL, Edwards PD, Jacobs RT, Mauger RC, Murphy MM, Palmer W, Pine KK, Rumsey WL, Garcia-Davenport LE, Shaw A, Steelman GB, Surian JM, Vacek EP. Veale CA, et al. Among authors: edwards pd. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52. doi: 10.1016/s0960-894x(00)00387-5. Bioorg Med Chem Lett. 2000. PMID: 10987424

3

Discovery and biological activity of orally active peptidyl trifluoromethyl ketone inhibitors of human neutrophil elastase.

Edwards PD, Andisik DW, Bryant CA, Ewing B, Gomes B, Lewis JJ, Rakiewicz D, Steelman G, Strimpler A, Trainor DA, Tuthill PA, Mauger RC, Veale CA, Wildonger RA, Williams JC, Wolanin DJ, Zottola M. Edwards PD, et al. J Med Chem. 1997 Jun 6;40(12):1876-85. doi: 10.1021/jm960819g. J Med Chem. 1997. PMID: 9191965

4

C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl alpha-ketoheterocycles.

Furlong ST, Dutta AS, Coath MM, Gormley JJ, Hubbs SJ, Lloyd D, Mauger RC, Strimpler AM, Sylvester MA, Scott CW, Edwards PD. Furlong ST, et al. Among authors: edwards pd. Immunopharmacology. 2000 Jul 20;48(2):199-212. doi: 10.1016/s0162-3109(00)00205-8. Immunopharmacology. 2000. PMID: 10936517

5

Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.

Brown DG, Bernstein PR, Griffin A, Wesolowski S, Labrecque D, Tremblay MC, Sylvester M, Mauger R, Edwards PD, Throner SR, Folmer JJ, Cacciola J, Scott C, Lazor LA, Pourashraf M, Santhakumar V, Potts WM, Sydserff S, Giguère P, Lévesque C, Dasser M, Groblewski T. Brown DG, et al. Among authors: edwards pd. J Med Chem. 2014 Feb 13;57(3):733-58. doi: 10.1021/jm4014828. Epub 2014 Jan 27. J Med Chem. 2014. PMID: 24410637

6

[¹²⁵I]YP20: a novel radioligand specific for the extracellular domain of the CRF₁ receptor.

Gordon JC, Edwards P, Elmore CS, Lazor LA, Paschetto K, Bostwick R, Sylvester M, Mauger R, Scott C, Aharony D. Gordon JC, et al. Eur J Pharmacol. 2010 Dec 15;649(1-3):59-63. doi: 10.1016/j.ejphar.2010.09.008. Epub 2010 Sep 18. Eur J Pharmacol. 2010. PMID: 20854803

7

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency.

Edwards PD, Wolanin DJ, Andisik DW, Davis MW. Edwards PD, et al. J Med Chem. 1995 Jan 6;38(1):76-85. doi: 10.1021/jm00001a013. J Med Chem. 1995. PMID: 7837243

8

Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones.

Edwards PD, Andisik DW, Strimpler AM, Gomes B, Tuthill PA. Edwards PD, et al. J Med Chem. 1996 Mar 1;39(5):1112-24. doi: 10.1021/jm950684z. J Med Chem. 1996. PMID: 8676347

9

Mechanism of slow-binding inhibition of human leukocyte elastase by trifluoromethyl ketones.

Stein RL, Strimpler AM, Edwards PD, Lewis JJ, Mauger RC, Schwartz JA, Stein MM, Trainor DA, Wildonger RA, Zottola MA. Stein RL, et al. Among authors: edwards pd. Biochemistry. 1987 May 19;26(10):2682-9. doi: 10.1021/bi00384a005. Biochemistry. 1987. PMID: 3649251

10

Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.

Edwards PD, Zottola MA, Davis M, Williams J, Tuthill PA. Edwards PD, et al. J Med Chem. 1995 Sep 29;38(20):3972-82. doi: 10.1021/jm00020a011. J Med Chem. 1995. PMID: 7562931

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