McGaraughty S - Search Results

1

Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.

McGaraughty S, Chu KL, Wismer CT, Mikusa J, Zhu CZ, Cowart M, Kowaluk EA, Jarvis MF. McGaraughty S, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):501-9. J Pharmacol Exp Ther. 2001. PMID: 11160637

2

Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor.

Jarvis MF, Yu H, McGaraughty S, Wismer CT, Mikusa J, Zhu C, Chu K, Kohlhaas K, Cowart M, Lee CH, Stewart AO, Cox BF, Polakowski J, Kowaluk EA. Jarvis MF, et al. Among authors: mcgaraughty s. Pain. 2002 Mar;96(1-2):107-18. doi: 10.1016/s0304-3959(01)00435-3. Pain. 2002. PMID: 11932067

3

Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats.

Jarvis MF, Mikusa J, Chu KL, Wismer CT, Honore P, Kowaluk EA, McGaraughty S. Jarvis MF, et al. Among authors: mcgaraughty s. Pharmacol Biochem Behav. 2002 Oct;73(3):573-81. doi: 10.1016/s0091-3057(02)00840-7. Pharmacol Biochem Behav. 2002. PMID: 12151032

4

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C. Jarvis MF, et al. Among authors: mcgaraughty s. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84. doi: 10.1073/pnas.252537299. Epub 2002 Dec 13. Proc Natl Acad Sci U S A. 2002. PMID: 12482951 Free PMC article.

5

Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.

Zheng GZ, Mao Y, Lee CH, Pratt JK, Koenig JR, Perner RJ, Cowart MD, Gfesser GA, McGaraughty S, Chu KL, Zhu C, Yu H, Kohlhaas K, Alexander KM, Wismer CT, Mikusa J, Jarvis MF, Kowaluk EA, Stewart AO. Zheng GZ, et al. Among authors: mcgaraughty s. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3041-4. doi: 10.1016/s0960-894x(03)00642-5. Bioorg Med Chem Lett. 2003. PMID: 12941329

6

Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration.

McGaraughty S, Wismer CT, Zhu CZ, Mikusa J, Honore P, Chu KL, Lee CH, Faltynek CR, Jarvis MF. McGaraughty S, et al. Br J Pharmacol. 2003 Dec;140(8):1381-8. doi: 10.1038/sj.bjp.0705574. Epub 2003 Nov 17. Br J Pharmacol. 2003. PMID: 14623769 Free PMC article.

7

Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors.

McGaraughty S, Cowart M, Jarvis MF, Berman RF. McGaraughty S, et al. Curr Top Med Chem. 2005;5(1):43-58. doi: 10.2174/1568026053386845. Curr Top Med Chem. 2005. PMID: 15638777 Review.

8

Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.

McGaraughty S, Honore P, Wismer CT, Mikusa J, Zhu CZ, McDonald HA, Bianchi B, Faltynek CR, Jarvis MF. McGaraughty S, et al. Br J Pharmacol. 2005 Sep;146(2):180-8. doi: 10.1038/sj.bjp.0706346. Br J Pharmacol. 2005. PMID: 16041397 Free PMC article.

9

Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.

McGaraughty S, Chu KL, Faltynek CR, Jarvis MF. McGaraughty S, et al. J Neurophysiol. 2006 Jan;95(1):18-25. doi: 10.1152/jn.00560.2005. Epub 2005 Sep 14. J Neurophysiol. 2006. PMID: 16162831 Free article.

10

A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.

McGaraughty S, Chu KL, Scanio MJ, Kort ME, Faltynek CR, Jarvis MF. McGaraughty S, et al. J Pharmacol Exp Ther. 2008 Mar;324(3):1204-11. doi: 10.1124/jpet.107.134148. Epub 2007 Dec 18. J Pharmacol Exp Ther. 2008. PMID: 18089840

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