Hallinan EA - Search Results

1

2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist.

Hallinan EA, Hagen TJ, Tsymbalov S, Stapelfeld A, Savage MA. Hallinan EA, et al. Bioorg Med Chem. 2001 Jan;9(1):1-6. doi: 10.1016/s0968-0896(00)00229-7. Bioorg Med Chem. 2001. PMID: 11197330

2

3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.

Tsymbalov S, Hagen TJ, Moore WM, Jerome GM, Connor JR, Manning PT, Pitzele BS, Hallinan EA. Tsymbalov S, et al. Among authors: hallinan ea. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3337-9. doi: 10.1016/s0960-894x(02)00686-8. Bioorg Med Chem Lett. 2002. PMID: 12392746

3

N-substituted dibenzoxazepines as analgesic PGE2 antagonists.

Hallinan EA, Hagen TJ, Husa RK, Tsymbalov S, Rao SN, vanHoeck JP, Rafferty MF, Stapelfeld A, Savage MA, Reichman M. Hallinan EA, et al. J Med Chem. 1993 Oct 29;36(22):3293-9. doi: 10.1021/jm00074a010. J Med Chem. 1993. PMID: 7901416

4

Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs.

Hallinan EA, Hagen TJ, Tsymbalov S, Husa RK, Lee AC, Stapelfeld A, Savage MA. Hallinan EA, et al. J Med Chem. 1996 Jan 19;39(2):609-13. doi: 10.1021/jm950454k. J Med Chem. 1996. PMID: 8558534

5

2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.

Hagen TJ, Bergmanis AA, Kramer SW, Fok KF, Schmelzer AE, Pitzele BS, Swenton L, Jerome GM, Kornmeier CM, Moore WM, Branson LF, Connor JR, Manning PT, Currie MG, Hallinan EA. Hagen TJ, et al. Among authors: hallinan ea. J Med Chem. 1998 Sep 10;41(19):3675-83. doi: 10.1021/jm970840x. J Med Chem. 1998. PMID: 9733492

6

Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.

Hallinan EA, Tsymbalov S, Dorn CR, Pitzele BS, Hansen DW Jr, Moore WM, Jerome GM, Connor JR, Branson LF, Widomski DL, Zhang Y, Currie MG, Manning PT. Hallinan EA, et al. J Med Chem. 2002 Apr 11;45(8):1686-9. doi: 10.1021/jm010420e. J Med Chem. 2002. PMID: 11931623

7

5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.

Hallinan EA, Hagen TJ, Bergmanis A, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. Hallinan EA, et al. J Med Chem. 2004 Feb 12;47(4):900-6. doi: 10.1021/jm030348f. J Med Chem. 2004. PMID: 14761191

8

Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.

Hallinan EA, Tsymbalov S, Finnegan PM, Moore WM, Jerome GM, Currie MG, Pitzele BS. Hallinan EA, et al. J Med Chem. 1998 Mar 12;41(6):775-7. doi: 10.1021/jm9706675. J Med Chem. 1998. PMID: 9526553 No abstract available.

9

Specific inhibitors of inducible nitric oxide synthase: efficacy in a rodent model of sepsis.

Fretland DJ, Widomski DL, Anglin CP, Moore W, Jerome G, Kornmeier C, Connor J, Branson L, Wyatt P, Manning P, Toth M, Webber RK, Hansen D, Hallinan EA, Hagen T, Bergmanis A, Pitzele B, Currie MG. Fretland DJ, et al. Among authors: hallinan ea. Inflamm Res. 1999 Dec;48 Suppl 2:S107-8. doi: 10.1007/s000110050540. Inflamm Res. 1999. PMID: 10667837 No abstract available.

10

4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain.

Hallinan EA, Kramer SW, Houdek SC, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. Hallinan EA, et al. Org Biomol Chem. 2003 Oct 21;1(20):3527-34. doi: 10.1039/b307563j. Org Biomol Chem. 2003. PMID: 14599013

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