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Page 1
Benzodiazepine inhibitors of the MMPs and TACE.
Nelson FC, Delos Santos E, Levin JI, Chen JM, Skotnicki JS, DiJoseph JF, Sharr MA, Sung A, Killar LM, Cowling R, Jin G, Roth CE, Albright JD. Nelson FC, et al. Among authors: sharr ma. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2867-70. doi: 10.1016/s0960-894x(02)00633-9. Bioorg Med Chem Lett. 2002. PMID: 12270165
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Aranapakam V, Grosu GT, Davis JM, Hu B, Ellingboe J, Baker JL, Skotnicki JS, Zask A, DiJoseph JF, Sung A, Sharr MA, Killar LM, Walter T, Jin G, Cowling R. Aranapakam V, et al. Among authors: sharr ma. J Med Chem. 2003 Jun 5;46(12):2361-75. doi: 10.1021/jm0205548. J Med Chem. 2003. PMID: 12773041
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Aranapakam V, Davis JM, Grosu GT, Baker J, Ellingboe J, Zask A, Levin JI, Sandanayaka VP, Du M, Skotnicki JS, DiJoseph JF, Sung A, Sharr MA, Killar LM, Walter T, Jin G, Cowling R, Tillett J, Zhao W, McDevitt J, Xu ZB. Aranapakam V, et al. Among authors: sharr ma. J Med Chem. 2003 Jun 5;46(12):2376-96. doi: 10.1021/jm0205550. J Med Chem. 2003. PMID: 12773042
The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.
Levin JI, Chen JM, Du MT, Nelson FC, Wehr T, DiJoseph JF, Killar LM, Skala S, Sung A, Sharr MA, Roth CE, Jin G, Cowling R, Di L, Sherman M, Xu ZB, March CJ, Mohler KM, Black RA, Skotnicki JS. Levin JI, et al. Among authors: sharr ma. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2975-8. doi: 10.1016/s0960-894x(01)00601-1. Bioorg Med Chem Lett. 2001. PMID: 11677139
Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors.
Zask A, Gu Y, Albright JD, Du X, Hogan M, Levin JI, Chen JM, Killar LM, Sung A, DiJoseph JF, Sharr MA, Roth CE, Skala S, Jin G, Cowling R, Mohler KM, Barone D, Black R, March C, Skotnicki JS. Zask A, et al. Among authors: sharr ma. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1487-90. doi: 10.1016/s0960-894x(03)00127-6. Bioorg Med Chem Lett. 2003. PMID: 12668018
12 results