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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D. Chishti MA, et al. J Biol Chem. 2001 Jun 15;276(24):21562-70. doi: 10.1074/jbc.M100710200. Epub 2001 Mar 15. J Biol Chem. 2001. PMID: 11279122 Free article.
Transgenic mouse models of Alzheimer's disease.
Janus C, Chishti MA, Westaway D. Janus C, et al. Among authors: chishti ma. Biochim Biophys Acta. 2000 Jul 26;1502(1):63-75. doi: 10.1016/s0925-4439(00)00033-8. Biochim Biophys Acta. 2000. PMID: 10899432 Free article. Review. No abstract available.
In vivo reduction of amyloid-beta by a mutant copper transporter.
Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. Phinney AL, et al. Among authors: chishti ma. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14193-8. doi: 10.1073/pnas.2332851100. Epub 2003 Nov 14. Proc Natl Acad Sci U S A. 2003. PMID: 14617772 Free PMC article.
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D. Mastrangelo P, et al. Among authors: chishti ma. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8972-7. doi: 10.1073/pnas.0500940102. Epub 2005 Jun 10. Proc Natl Acad Sci U S A. 2005. PMID: 15951428 Free PMC article.
New developments in animal models of Alzheimer's disease.
Janus C, Phinney AL, Chishti MA, Westaway D. Janus C, et al. Among authors: chishti ma. Curr Neurol Neurosci Rep. 2001 Sep;1(5):451-7. doi: 10.1007/s11910-001-0105-8. Curr Neurol Neurosci Rep. 2001. PMID: 11898556 Review.
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P. McLaurin J, et al. Among authors: chishti ma. Nat Med. 2002 Nov;8(11):1263-9. doi: 10.1038/nm790. Epub 2002 Oct 15. Nat Med. 2002. PMID: 12379850
43 results