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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D. Chishti MA, et al. Among authors: janus c. J Biol Chem. 2001 Jun 15;276(24):21562-70. doi: 10.1074/jbc.M100710200. Epub 2001 Mar 15. J Biol Chem. 2001. PMID: 11279122 Free article.
Notably, learning impairment in young mice was offset by immunization against Abeta42 (Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. ...J., Nixon, R. A., Mercken, M., Bergeron, C., Fraser, P. E., St. George-Hyslo …
Notably, learning impairment in young mice was offset by immunization against Abeta42 (Janus, C., Pearson, J., McLaurin, J., M …
Transgenic mouse models of Alzheimer's disease.
Janus C, Westaway D. Janus C, et al. Physiol Behav. 2001 Aug;73(5):873-86. doi: 10.1016/s0031-9384(01)00524-8. Physiol Behav. 2001. PMID: 11566220 Review.
Transgenic mouse models of Alzheimer's disease.
Janus C, Chishti MA, Westaway D. Janus C, et al. Biochim Biophys Acta. 2000 Jul 26;1502(1):63-75. doi: 10.1016/s0925-4439(00)00033-8. Biochim Biophys Acta. 2000. PMID: 10899432 Free article. Review. No abstract available.
New developments in animal models of Alzheimer's disease.
Janus C, Phinney AL, Chishti MA, Westaway D. Janus C, et al. Curr Neurol Neurosci Rep. 2001 Sep;1(5):451-7. doi: 10.1007/s11910-001-0105-8. Curr Neurol Neurosci Rep. 2001. PMID: 11898556 Review.
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P. McLaurin J, et al. Among authors: janus c. Nat Med. 2002 Nov;8(11):1263-9. doi: 10.1038/nm790. Epub 2002 Oct 15. Nat Med. 2002. PMID: 12379850
218 results