Bledsoe RK - Search Results

1

Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.

Spencer TA, Li D, Russel JS, Collins JL, Bledsoe RK, Consler TG, Moore LB, Galardi CM, McKee DD, Moore JT, Watson MA, Parks DJ, Lambert MH, Willson TM. Spencer TA, et al. Among authors: bledsoe rk. J Med Chem. 2001 Mar 15;44(6):886-97. doi: 10.1021/jm0004749. J Med Chem. 2001. PMID: 11300870

2

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.

Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM. Williams S, et al. Among authors: bledsoe rk. J Biol Chem. 2003 Jul 18;278(29):27138-43. doi: 10.1074/jbc.M302260200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12736258 Free article.

3

Bile acids: natural ligands for an orphan nuclear receptor.

Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM. Parks DJ, et al. Among authors: bledsoe rk. Science. 1999 May 21;284(5418):1365-8. doi: 10.1126/science.284.5418.1365. Science. 1999. PMID: 10334993

4

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA. Moore LB, et al. Among authors: bledsoe rk. J Biol Chem. 2000 May 19;275(20):15122-7. doi: 10.1074/jbc.M001215200. J Biol Chem. 2000. PMID: 10748001 Free article.

5

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE. Bledsoe RK, et al. Cell. 2002 Jul 12;110(1):93-105. doi: 10.1016/s0092-8674(02)00817-6. Cell. 2002. PMID: 12151000 Free article.

6

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Gampe RT Jr, et al. Among authors: bledsoe rk. Mol Cell. 2000 Mar;5(3):545-55. doi: 10.1016/s1097-2765(00)80448-7. Mol Cell. 2000. PMID: 10882139 Free article.

7

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. Leesnitzer LM, et al. Among authors: bledsoe rk. Biochemistry. 2002 May 28;41(21):6640-50. doi: 10.1021/bi0159581. Biochemistry. 2002. PMID: 12022867

8

Structure-based design of potent retinoid X receptor alpha agonists.

Haffner CD, Lenhard JM, Miller AB, McDougald DL, Dwornik K, Ittoop OR, Gampe RT Jr, Xu HE, Blanchard S, Montana VG, Consler TG, Bledsoe RK, Ayscue A, Croom D. Haffner CD, et al. Among authors: bledsoe rk. J Med Chem. 2004 Apr 8;47(8):2010-29. doi: 10.1021/jm030565g. J Med Chem. 2004. PMID: 15056000

9

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.

Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SP. Bledsoe RK, et al. J Biol Chem. 2005 Sep 2;280(35):31283-93. doi: 10.1074/jbc.M504098200. Epub 2005 Jun 20. J Biol Chem. 2005. PMID: 15967794 Free article.

10

X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.

Biggadike K, Bledsoe RK, Hassell AM, Kirk BE, McLay IM, Shewchuk LM, Stewart EL. Biggadike K, et al. Among authors: bledsoe rk. J Med Chem. 2008 Jun 26;51(12):3349-52. doi: 10.1021/jm800279t. Epub 2008 Jun 4. J Med Chem. 2008. PMID: 18522385

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