Wang S - Search Results

1

Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.

Enyedy IJ, Lee SL, Kuo AH, Dickson RB, Lin CY, Wang S. Enyedy IJ, et al. Among authors: wang s. J Med Chem. 2001 Apr 26;44(9):1349-55. doi: 10.1021/jm000395x. J Med Chem. 2001. PMID: 11311057

2

Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.

Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Deschaux O, Bandyopadhyay BC, Tella SR, Zaman WA, Johnson KM. Wang S, et al. J Med Chem. 2000 Feb 10;43(3):351-60. doi: 10.1021/jm990516x. J Med Chem. 2000. PMID: 10669562

3

Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors.

Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM, Wang S. Sakamuri S, et al. Among authors: wang s. Bioorg Med Chem Lett. 2001 Feb 26;11(4):495-500. doi: 10.1016/s0960-894x(00)00703-4. Bioorg Med Chem Lett. 2001. PMID: 11229756

4

Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides.

Rong SB, Hu Y, Enyedy I, Powis G, Meuillet EJ, Wu X, Wang R, Wang S, Kozikowski AP. Rong SB, et al. Among authors: wang s, wang r. J Med Chem. 2001 Mar 15;44(6):898-908. doi: 10.1021/jm000493i. J Med Chem. 2001. PMID: 11300871

5

Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.

Enyedy IJ, Zaman WA, Sakamuri S, Kozikowski AP, Johnson KM, Wang S. Enyedy IJ, et al. Among authors: wang s. Bioorg Med Chem Lett. 2001 May 7;11(9):1113-8. doi: 10.1016/s0960-894x(01)00132-9. Bioorg Med Chem Lett. 2001. PMID: 11354356

6

Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.

Pak Y, Enyedy IJ, Varady J, Kung JW, Lorenzo PS, Blumberg PM, Wang S. Pak Y, et al. Among authors: wang s. J Med Chem. 2001 May 24;44(11):1690-701. doi: 10.1021/jm000488e. J Med Chem. 2001. PMID: 11356104

7

Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors.

Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Zaman WA, Johnson KM. Wang S, et al. Bioorg Med Chem. 2001 Jul;9(7):1753-64. doi: 10.1016/s0968-0896(01)00090-6. Bioorg Med Chem. 2001. PMID: 11425577

8

Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.

Long YQ, Lee SL, Lin CY, Enyedy IJ, Wang S, Li P, Dickson RB, Roller PP. Long YQ, et al. Among authors: wang s. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2515-9. doi: 10.1016/s0960-894x(01)00493-0. Bioorg Med Chem Lett. 2001. PMID: 11549459

9

Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.

Shao L, Lewin NE, Lorenzo PS, Hu Z, Enyedy IJ, Garfield SH, Stone JC, Marner FJ, Blumberg PM, Wang S. Shao L, et al. Among authors: wang s. J Med Chem. 2001 Nov 8;44(23):3872-80. doi: 10.1021/jm010258f. J Med Chem. 2001. PMID: 11689073

10

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

Enyedy IJ, Ling Y, Nacro K, Tomita Y, Wu X, Cao Y, Guo R, Li B, Zhu X, Huang Y, Long YQ, Roller PP, Yang D, Wang S. Enyedy IJ, et al. Among authors: wang s. J Med Chem. 2001 Dec 6;44(25):4313-24. doi: 10.1021/jm010016f. J Med Chem. 2001. PMID: 11728179

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