Saavedra JE - Search Results

1

The secondary amine/nitric oxide complex ion R(2)N[N(O)NO](-) as nucleophile and leaving group in S9N)Ar reactions.

Saavedra JE, Srinivasan A, Bonifant CL, Chu J, Shanklin AP, Flippen-Anderson JL, Rice WG, Turpin JA, Davies KM, Keefer LK. Saavedra JE, et al. J Org Chem. 2001 May 4;66(9):3090-8. doi: 10.1021/jo0016529. J Org Chem. 2001. PMID: 11325274

2

Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.

Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Org Lett. 2007 Oct 25;9(22):4551-4. doi: 10.1021/ol7019636. Epub 2007 Oct 5. Org Lett. 2007. PMID: 17918856

3

Piperazine as a Linker for Incorporating the Nitric Oxide-Releasing Diazeniumdiolate Group into Other Biomedically Relevant Functional Molecules.

Saavedra JE, Booth MN, Hrabie JA, Davies KM, Keefer LK. Saavedra JE, et al. J Org Chem. 1999 Jul 9;64(14):5124-5131. doi: 10.1021/jo9901539. J Org Chem. 1999. PMID: 34237868

4

Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: in vitro antileukemic activity.

Saavedra JE, Shami PJ, Wang LY, Davies KM, Booth MN, Citro ML, Keefer LK. Saavedra JE, et al. J Med Chem. 2000 Jan 27;43(2):261-9. doi: 10.1021/jm9903850. J Med Chem. 2000. PMID: 10649981

5

Chemistry of the diazeniumdiolates. I. Structural and spectral characteristics of the [N(O)NO]- functional group.

Keefer LK, Flippen-Anderson JL, George C, Shanklin AP, Dunams TM, Christodoulou D, Saavedra JE, Sagan ES, Bohle DS. Keefer LK, et al. Among authors: saavedra je. Nitric Oxide. 2001 Aug;5(4):377-94. doi: 10.1006/niox.2001.0359. Nitric Oxide. 2001. PMID: 11485376

6

Preparation and reactivity of O2-sulfonated diazeniumdiolates.

D'Sa RA, Wang Y, Ruane PH, Showalter BM, Saavedra JE, Davies KM, Citro ML, Booth MN, Keefer LK, Toscano JP. D'Sa RA, et al. Among authors: saavedra je. J Org Chem. 2003 Jan 24;68(2):656-7. doi: 10.1021/jo026656n. J Org Chem. 2003. PMID: 12530906

7

Chemistry of the diazeniumdiolates: Z right harpoon over left harpoon E isomerism.

Wang YN, Bohle DS, Bonifant CL, Chmurny GN, Collins JR, Davies KM, Deschamps J, Flippen-Anderson JL, Keefer LK, Klose JR, Saavedra JE, Waterhouse DJ, Ivanic J. Wang YN, et al. Among authors: saavedra je. J Am Chem Soc. 2005 Apr 20;127(15):5388-95. doi: 10.1021/ja042258l. J Am Chem Soc. 2005. PMID: 15826177

8

PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.

Saavedra JE, Srinivasan A, Buzard GS, Davies KM, Waterhouse DJ, Inami K, Wilde TC, Citro ML, Cuellar M, Deschamps JR, Parrish D, Shami PJ, Findlay VJ, Townsend DM, Tew KD, Singh S, Jia L, Ji X, Keefer LK. Saavedra JE, et al. J Med Chem. 2006 Feb 9;49(3):1157-64. doi: 10.1021/jm050700k. J Med Chem. 2006. PMID: 16451080 Free PMC article.

9

V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO.

Chakrapani H, Showalter BM, Kong L, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Org Lett. 2007 Aug 16;9(17):3409-12. doi: 10.1021/ol701419a. Epub 2007 Jul 20. Org Lett. 2007. PMID: 17658755

10

Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.

Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Bioorg Med Chem. 2008 Mar 1;16(5):2657-64. doi: 10.1016/j.bmc.2007.11.035. Epub 2007 Nov 17. Bioorg Med Chem. 2008. PMID: 18060792 Free PMC article.

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