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Page 1
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.
Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM. Ames RS, et al. Among authors: badger am. J Immunol. 2001 May 15;166(10):6341-8. doi: 10.4049/jimmunol.166.10.6341. J Immunol. 2001. PMID: 11342658
SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.
Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, White RF, McVey MJ, Legos JJ, Erhardt JA, Nelson AH, Ohlstein EH, Hunter AJ, Ward K, Smith BR, Adams JL, Parsons AA. Barone FC, et al. Among authors: badger am. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21. J Pharmacol Exp Ther. 2001. PMID: 11160612
Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.
Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, Richardson S, Levy MA, DeWolf WE Jr, Keller PM, Tomaszek T, Head MS, Ryan MD, Haltiwanger RC, Liang PH, Janson CA, McDevitt PJ, Johanson K, Concha NO, Chan W, Abdel-Meguid SS, Badger AM, Lark MW, Nadeau DP, Suva LJ, Gowen M, Nuttall ME. Lee D, et al. Among authors: badger am. J Biol Chem. 2000 May 26;275(21):16007-14. doi: 10.1074/jbc.275.21.16007. J Biol Chem. 2000. PMID: 10821855 Free article.
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL. Boehm JC, et al. Among authors: badger am. J Med Chem. 1996 Sep 27;39(20):3929-37. doi: 10.1021/jm960415o. J Med Chem. 1996. PMID: 8831759
Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia.
Barone FC, Irving EA, Ray AM, Lee JC, Kassis S, Kumar S, Badger AM, Legos JJ, Erhardt JA, Ohlstein EH, Hunter AJ, Harrison DC, Philpott K, Smith BR, Adams JL, Parsons AA. Barone FC, et al. Among authors: badger am. Med Res Rev. 2001 Mar;21(2):129-45. doi: 10.1002/1098-1128(200103)21:2<129::aid-med1003>3.0.co;2-h. Med Res Rev. 2001. PMID: 11223862 Review.
116 results