Wynford-Thomas D - Search Results

1

Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications.

Matthews P, Jones CJ, Skinner J, Haughton M, de Micco C, Wynford-Thomas D. Matthews P, et al. J Pathol. 2001 Jun;194(2):183-93. doi: 10.1002/path.848. J Pathol. 2001. PMID: 11400147

2

Dissociation of telomere dynamics from telomerase activity in human thyroid cancer cells.

Jones CJ, Soley A, Skinner JW, Gupta J, Haughton MF, Wyllie FS, Schlumberger M, Bacchetti S, Wynford-Thomas D. Jones CJ, et al. Exp Cell Res. 1998 May 1;240(2):333-9. doi: 10.1006/excr.1998.3944. Exp Cell Res. 1998. PMID: 9597006

3

Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D. Davis T, et al. J Cell Sci. 2003 Apr 1;116(Pt 7):1349-57. doi: 10.1242/jcs.00331. J Cell Sci. 2003. PMID: 12615976 Free article.

4

Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation.

Bond J, Jones C, Haughton M, DeMicco C, Kipling D, Wynford-Thomas D. Bond J, et al. Exp Cell Res. 2004 Jan 1;292(1):151-6. doi: 10.1016/j.yexcr.2003.09.021. Exp Cell Res. 2004. PMID: 14720514

5

Telomere erosion triggers growth arrest but not cell death in human cancer cells retaining wild-type p53: implications for antitelomerase therapy.

Preto A, Singhrao SK, Haughton MF, Kipling D, Wynford-Thomas D, Jones CJ. Preto A, et al. Oncogene. 2004 May 20;23(23):4136-45. doi: 10.1038/sj.onc.1207564. Oncogene. 2004. PMID: 15064743

6

Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis.

Skinner J, Bounacer A, Bond JA, Haughton MF, deMicco C, Wynford-Thomas D. Skinner J, et al. Oncogene. 2004 Aug 5;23(35):5994-9. doi: 10.1038/sj.onc.1207798. Oncogene. 2004. PMID: 15208687

7

Does telomere shortening drive selection for p53 mutation in human cancer?

Wynford-Thomas D, Bond JA, Wyllie FS, Jones CJ. Wynford-Thomas D, et al. Mol Carcinog. 1995 Mar;12(3):119-23. doi: 10.1002/mc.2940120302. Mol Carcinog. 1995. PMID: 7893364 Review. No abstract available.

8

High frequency deletion of the tumour suppressor gene P16INK4a (MTS1) in human thyroid cancer cell lines.

Jones CJ, Shaw JJ, Wyllie FS, Gaillard N, Schlumberger M, Wynford-Thomas D. Jones CJ, et al. Mol Cell Endocrinol. 1996 Jan 15;116(1):115-9. doi: 10.1016/0303-7207(95)03697-0. Mol Cell Endocrinol. 1996. PMID: 8822272

9

Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53.

Wyllie FS, Haughton MF, Rowson JM, Wynford-Thomas D. Wyllie FS, et al. Br J Cancer. 1999 Mar;79(7-8):1111-20. doi: 10.1038/sj.bjc.6690177. Br J Cancer. 1999. PMID: 10098744 Free PMC article.

10

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts.

Wyllie FS, Jones CJ, Skinner JW, Haughton MF, Wallis C, Wynford-Thomas D, Faragher RG, Kipling D. Wyllie FS, et al. Nat Genet. 2000 Jan;24(1):16-7. doi: 10.1038/71630. Nat Genet. 2000. PMID: 10615119 No abstract available.

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