Brealey CJ - Search Results

1

Effects of cyclosporin A administered into the airways against antigen-induced airway inflammation and hyperreactivity in the rat.

Underwood SL, McMillan S, Reeves R, Hunt J, Brealey CJ, Webber S, Foster M, Sargent CA. Underwood SL, et al. Among authors: brealey cj. Eur J Pharmacol. 2001 May 25;420(2-3):165-73. doi: 10.1016/s0014-2999(01)00975-x. Eur J Pharmacol. 2001. PMID: 11408039

2

Selective endothelin A receptor antagonists. 3. Discovery and structure-activity relationships of a series of 4-phenoxybutanoic acid derivatives.

Astles PC, Brealey C, Brown TJ, Facchini V, Handscombe C, Harris NV, McCarthy C, McLay IM, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. J Med Chem. 1998 Jul 16;41(15):2732-44. doi: 10.1021/jm9707131. J Med Chem. 1998. PMID: 9667964

3

RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.

Canton T, Böhme GA, Boireau A, Bordier F, Mignani S, Jimonet P, Jahn G, Alavijeh M, Stygall J, Roberts S, Brealey C, Vuilhorgne M, Debono MW, Le Guern S, Laville M, Briet D, Roux M, Stutzmann JM, Pratt J. Canton T, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):314-22. J Pharmacol Exp Ther. 2001. PMID: 11561094

4

An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator.

Grime K, Pehrson R, Nordell P, Gillen M, Kühn W, Mant T, Brännström M, Svanberg P, Jones B, Brealey C. Grime K, et al. Br J Clin Pharmacol. 2017 Feb;83(2):381-392. doi: 10.1111/bcp.13102. Epub 2016 Oct 13. Br J Clin Pharmacol. 2017. PMID: 27558866 Free PMC article. Clinical Trial.

5

Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Elsby R, Baluom M, Lau D, Mant T. Martin P, et al. Clin Ther. 2015 Dec 1;37(12):2811-22. doi: 10.1016/j.clinthera.2015.09.018. Epub 2015 Oct 26. Clin Ther. 2015. PMID: 26514315 Clinical Trial.

6

Effects of Fostamatinib on the Pharmacokinetics of Oral Contraceptive, Warfarin, and the Statins Rosuvastatin and Simvastatin: Results From Phase I Clinical Studies.

Martin P, Gillen M, Ritter J, Mathews D, Brealey C, Surry D, Oliver S, Holmes V, Severin P, Elsby R. Martin P, et al. Drugs R D. 2016 Mar;16(1):93-107. doi: 10.1007/s40268-015-0120-x. Drugs R D. 2016. PMID: 26748647 Free PMC article. Clinical Trial.

7

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Grossbard EB, Baluom M, Lau D, Sweeny D, Mant T, Craven K. Martin P, et al. Drugs R D. 2016 Mar;16(1):81-92. doi: 10.1007/s40268-015-0118-4. Drugs R D. 2016. PMID: 26739683 Free PMC article. Clinical Trial.

8

Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Surry D, Sweeny D, Lau D, Leese P. Martin P, et al. Clin Pharmacol Drug Dev. 2016 May;5(3):170-9. doi: 10.1002/cpdd.243. Epub 2016 Mar 23. Clin Pharmacol Drug Dev. 2016. PMID: 27163495 Clinical Trial.

9

Toxicity of pesticides to birds; the enzymic factor.

Walker CH, Brealey CJ, Mackness MI, Johnston G. Walker CH, et al. Among authors: brealey cj. Biochem Soc Trans. 1991 Aug;19(3):741-5. doi: 10.1042/bst0190741. Biochem Soc Trans. 1991. PMID: 1664395 Review. No abstract available.

10

Uncoupler resistance in E. coli Tuv and Cuv is due to the exclusion of uncoupler by the outer membrane.

Haworth RS, Jensen PR, Michelsen O, Wyatt JA, Brealey CJ, Beechey RB. Haworth RS, et al. Among authors: brealey cj. Biochim Biophys Acta. 1990 Aug 9;1019(1):67-72. doi: 10.1016/0005-2728(90)90125-n. Biochim Biophys Acta. 1990. PMID: 2118805

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