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The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
Biernat J, Mandelkow EM, Schröter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M, Mandelkow E. Biernat J, et al. Among authors: mandelkow em, mandelkow e. EMBO J. 1992 Apr;11(4):1593-7. doi: 10.1002/j.1460-2075.1992.tb05204.x. EMBO J. 1992. PMID: 1563356 Free PMC article.
Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.
Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Söling HD, Drechsel D, Kirschner MW, Goedert M, Mandelkow E. Steiner B, et al. Among authors: mandelkow em, mandelkow e. EMBO J. 1990 Nov;9(11):3539-44. doi: 10.1002/j.1460-2075.1990.tb07563.x. EMBO J. 1990. PMID: 2120043 Free PMC article.
Tau domains, phosphorylation, and interactions with microtubules.
Mandelkow EM, Biernat J, Drewes G, Gustke N, Trinczek B, Mandelkow E. Mandelkow EM, et al. Among authors: mandelkow e. Neurobiol Aging. 1995 May-Jun;16(3):355-62; discussion 362-3. doi: 10.1016/0197-4580(95)00025-a. Neurobiol Aging. 1995. PMID: 7566345 Review.
232 results