Giembycz MA - Search Results

1

Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.

Staples KJ, Bergmann M, Tomita K, Houslay MD, McPhee I, Barnes PJ, Giembycz MA, Newton R. Staples KJ, et al. Among authors: giembycz ma. J Immunol. 2001 Aug 15;167(4):2074-80. doi: 10.4049/jimmunol.167.4.2074. J Immunol. 2001. PMID: 11489990

2

Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89.

Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, Giembycz MA. Meja KK, et al. Among authors: giembycz ma. J Pharmacol Exp Ther. 2004 May;309(2):833-44. doi: 10.1124/jpet.103.060020. Epub 2004 Jan 27. J Pharmacol Exp Ther. 2004. PMID: 14747610 Free article.

3

Selective inhibition of a high affinity type IV cyclic AMP phosphodiesterase in bovine trachealis by AH 21-132. Relevance to the spasmolytic and anti-spasmogenic actions of AH 21-132 in the intact tissue.

Giembycz MA, Barnes PJ. Giembycz MA, et al. Biochem Pharmacol. 1991 Jul 15;42(3):663-77. doi: 10.1016/0006-2952(91)90330-8. Biochem Pharmacol. 1991. PMID: 1650218

4

Characterization of eosinophil cell activation by peptides. Differential effects of substance P, melittin, and FMET-Leu-Phe.

Kroegel C, Giembycz MA, Barnes PJ. Kroegel C, et al. Among authors: giembycz ma. J Immunol. 1990 Oct 15;145(8):2581-7. J Immunol. 1990. PMID: 1698858

5

Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins.

Giembycz MA, Kroegel C, Barnes PJ. Giembycz MA, et al. J Immunol. 1990 May 1;144(9):3489-97. J Immunol. 1990. PMID: 2158510

6

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2.

Giembycz MA, Corrigan CJ, Seybold J, Newton R, Barnes PJ. Giembycz MA, et al. Br J Pharmacol. 1996 Aug;118(8):1945-58. doi: 10.1111/j.1476-5381.1996.tb15629.x. Br J Pharmacol. 1996. PMID: 8864528 Free PMC article.

7

Leukotriene B4 activates the NADPH oxidase in eosinophils by a pertussis toxin-sensitive mechanism that is largely independent of arachidonic acid mobilization.

Lindsay MA, Perkins RS, Barnes PJ, Giembycz MA. Lindsay MA, et al. Among authors: giembycz ma. J Immunol. 1998 May 1;160(9):4526-34. J Immunol. 1998. PMID: 9574559

8

Interleukin-10 does not mediate the inhibitory effect of PDE-4 inhibitors and other cAMP-elevating drugs on lipopolysaccharide-induced tumors necrosis factor-alpha generation from human peripheral blood monocytes.

Seldon PM, Barnes PJ, Giembycz MA. Seldon PM, et al. Among authors: giembycz ma. Cell Biochem Biophys. 1998;29(1-2):179-201. doi: 10.1007/BF02737835. Cell Biochem Biophys. 1998. PMID: 9631245

9

Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.

Seybold J, Newton R, Wright L, Finney PA, Suttorp N, Barnes PJ, Adcock IM, Giembycz MA. Seybold J, et al. Among authors: giembycz ma. J Biol Chem. 1998 Aug 7;273(32):20575-88. doi: 10.1074/jbc.273.32.20575. J Biol Chem. 1998. PMID: 9685415 Free article.

10

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes.

Smith SJ, Cieslinski LB, Newton R, Donnelly LE, Fenwick PS, Nicholson AG, Barnes PJ, Barnette MS, Giembycz MA. Smith SJ, et al. Among authors: giembycz ma. Mol Pharmacol. 2004 Dec;66(6):1679-89. doi: 10.1124/mol.104.002246. Epub 2004 Sep 15. Mol Pharmacol. 2004. PMID: 15371556

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