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Page 1
A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
Kawahata N, Yang MG, Luke GP, Shakespeare WC, Sundaramoorthi R, Wang Y, Johnson D, Merry T, Violette S, Guan W, Bartlett C, Smith J, Hatada M, Lu X, Dalgarno DC, Eyermann CJ, Bohacek RS, Sawyer TK. Kawahata N, et al. Among authors: violette s. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2319-23. doi: 10.1016/s0960-894x(01)00446-2. Bioorg Med Chem Lett. 2001. PMID: 11527723
Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.
Vu CB, Luke GP, Kawahata N, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keenan TP, Pradeepan S, Corpuz E, Merry T, Bohacek RS, Dalgarno DC, Narula SS, van Schravendijk MR, Ram MK, Adams S, Liou S, Keats JA, Violette SM, Guan W, Weigele M, Sawyer TK. Vu CB, et al. Among authors: violette sm. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3071-4. doi: 10.1016/s0960-894x(03)00649-8. Bioorg Med Chem Lett. 2003. PMID: 12941336
Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.
Violette SM, Guan W, Bartlett C, Smith JA, Bardelay C, Antoine E, Rickles RJ, Mandine E, van Schravendijk MR, Adams SE, Lynch BA, Shakespeare WC, Yang M, Jacobsen VA, Takeuchi CS, Macek KJ, Bohacek RS, Dalgarno DC, Weigele M, Lesuisse D, Sawyer TK, Baron R. Violette SM, et al. Bone. 2001 Jan;28(1):54-64. doi: 10.1016/s8756-3282(00)00427-0. Bone. 2001. PMID: 11165943
Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70.
Vu CB, Corpuz EG, Merry TJ, Pradeepan SG, Bartlett C, Bohacek RS, Botfield MC, Eyermann CJ, Lynch BA, MacNeil IA, Ram MK, van Schravendijk MR, Violette S, Sawyer TK. Vu CB, et al. Among authors: violette s. J Med Chem. 1999 Oct 7;42(20):4088-98. doi: 10.1021/jm990229t. J Med Chem. 1999. PMID: 10514279
Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70.
Vu CB, Corpuz EG, Pradeepan SG, Violette S, Bartlett C, Sawyer TK. Vu CB, et al. Among authors: violette s. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3009-14. doi: 10.1016/s0960-894x(99)00524-7. Bioorg Med Chem Lett. 1999. PMID: 10571165
96 results