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Page 1
Identification of alkylidene hydrazides as glucagon receptor antagonists.
Ling A, Hong Y, Gonzalez J, Gregor V, Polinsky A, Kuki A, Shi S, Teston K, Murphy D, Porter J, Kiel D, Lakis J, Anderes K, May J, Knudsen LB, Lau J. Ling A, et al. Among authors: shi s. J Med Chem. 2001 Sep 13;44(19):3141-9. doi: 10.1021/jm000547o. J Med Chem. 2001. PMID: 11543683
Human glucagon receptor antagonists based on alkylidene hydrazides.
Ling A, Plewe M, Gonzalez J, Madsen P, Sams CK, Lau J, Gregor V, Murphy D, Teston K, Kuki A, Shi S, Truesdale L, Kiel D, May J, Lakis J, Anderes K, Iatsimirskaia E, Sidelmann UG, Knudsen LB, Brand CL, Polinsky A. Ling A, et al. Among authors: shi s. Bioorg Med Chem Lett. 2002 Feb 25;12(4):663-6. doi: 10.1016/s0960-894x(01)00819-8. Bioorg Med Chem Lett. 2002. PMID: 11844695
Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.
Madsen P, Ling A, Plewe M, Sams CK, Knudsen LB, Sidelmann UG, Ynddal L, Brand CL, Andersen B, Murphy D, Teng M, Truesdale L, Kiel D, May J, Kuki A, Shi S, Johnson MD, Teston KA, Feng J, Lakis J, Anderes K, Gregor V, Lau J. Madsen P, et al. Among authors: shi s. J Med Chem. 2002 Dec 19;45(26):5755-75. doi: 10.1021/jm0208572. J Med Chem. 2002. PMID: 12477359
Combinatorial library-based design with Basis Products.
Zhou JZ, Shi S, Na J, Peng Z, Thacher T. Zhou JZ, et al. Among authors: shi s. J Comput Aided Mol Des. 2009 Oct;23(10):725-36. doi: 10.1007/s10822-009-9297-9. Epub 2009 Jul 11. J Comput Aided Mol Des. 2009. PMID: 19593647
8,652 results