Mansell AS - Search Results

1

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.

Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA. Fitzgerald KA, et al. Among authors: mansell as. Nature. 2001 Sep 6;413(6851):78-83. doi: 10.1038/35092578. Nature. 2001. PMID: 11544529

2

A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages.

Mansell A, Braun L, Cossart P, O'Neill LA. Mansell A, et al. Cell Microbiol. 2000 Apr;2(2):127-36. doi: 10.1046/j.1462-5822.2000.00038.x. Cell Microbiol. 2000. PMID: 11207569

3

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

Mansell A, Khelef N, Cossart P, O'Neill LA. Mansell A, et al. J Biol Chem. 2001 Nov 23;276(47):43597-603. doi: 10.1074/jbc.M105202200. Epub 2001 Sep 24. J Biol Chem. 2001. PMID: 11571285 Free article.

4

The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4.

Mansell A, Reinicke A, Worrall DM, O'Neill LA. Mansell A, et al. FEBS Lett. 2001 Nov 23;508(3):313-7. doi: 10.1016/s0014-5793(01)03077-0. FEBS Lett. 2001. PMID: 11728442 Free article.

5

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

Mansell A, Brint E, Gould JA, O'Neill LA, Hertzog PJ. Mansell A, et al. J Biol Chem. 2004 Sep 3;279(36):37227-30. doi: 10.1074/jbc.C400289200. Epub 2004 Jul 9. J Biol Chem. 2004. PMID: 15247281 Free article.

6

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.

Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, Crack PJ, Nicholson SE, Hilton DJ, O'Neill LA, Hertzog PJ. Mansell A, et al. Nat Immunol. 2006 Feb;7(2):148-55. doi: 10.1038/ni1299. Epub 2006 Jan 15. Nat Immunol. 2006. PMID: 16415872

7

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.

Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LAJ. Dowling JK, et al. J Biol Chem. 2014 Mar 7;289(10):6429-6437. doi: 10.1074/jbc.M113.539692. Epub 2014 Jan 9. J Biol Chem. 2014. PMID: 24407287 Free PMC article.

8

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

Verstak B, Stack J, Ve T, Mangan M, Hjerrild K, Jeon J, Stahl R, Latz E, Gay N, Kobe B, Bowie AG, Mansell A. Verstak B, et al. J Leukoc Biol. 2014 Sep;96(3):427-36. doi: 10.1189/jlb.2A0913-487R. Epub 2014 May 8. J Leukoc Biol. 2014. PMID: 24812060 Free PMC article.

9

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ. Hughes MM, et al. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24. Proc Natl Acad Sci U S A. 2017. PMID: 28739909 Free PMC article.

10

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B. Ve T, et al. Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31. Nat Struct Mol Biol. 2017. PMID: 28759049 Free PMC article.

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