Lalonde J - Search Results

1

Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL. Qiu X, et al. Among authors: lalonde j. Protein Sci. 2001 Oct;10(10):2008-16. doi: 10.1110/ps.18001. Protein Sci. 2001. PMID: 11567092 Free PMC article.

2

The crystal structure of human procathepsin K.

LaLonde JM, Zhao B, Janson CA, D'Alessio KJ, McQueney MS, Orsini MJ, Debouck CM, Smith WW. LaLonde JM, et al. Biochemistry. 1999 Jan 19;38(3):862-9. doi: 10.1021/bi9822271. Biochemistry. 1999. PMID: 9893980

3

Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.

LaLonde JM, Zhao B, Smith WW, Janson CA, DesJarlais RL, Tomaszek TA, Carr TJ, Thompson SK, Oh HJ, Yamashita DS, Veber DF, Abdel-Meguid SS. LaLonde JM, et al. J Med Chem. 1998 Nov 5;41(23):4567-76. doi: 10.1021/jm980249f. J Med Chem. 1998. PMID: 9804696

4

Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase.

Kumar S, Jaller D, Patel B, LaLonde JM, DuHadaway JB, Malachowski WP, Prendergast GC, Muller AJ. Kumar S, et al. Among authors: lalonde jm. J Med Chem. 2008 Aug 28;51(16):4968-77. doi: 10.1021/jm800512z. Epub 2008 Jul 30. J Med Chem. 2008. PMID: 18665584 Free PMC article.

5

Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.

Gopi H, Umashankara M, Pirrone V, LaLonde J, Madani N, Tuzer F, Baxter S, Zentner I, Cocklin S, Jawanda N, Miller SR, Schön A, Klein JC, Freire E, Krebs FC, Smith AB, Sodroski J, Chaiken I. Gopi H, et al. Among authors: lalonde j. J Med Chem. 2008 May 8;51(9):2638-47. doi: 10.1021/jm070814r. Epub 2008 Apr 11. J Med Chem. 2008. PMID: 18402432 Free PMC article.

6

Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.

LaLonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith AB 3rd. LaLonde JM, et al. J Med Chem. 2012 May 10;55(9):4382-96. doi: 10.1021/jm300265j. Epub 2012 Apr 23. J Med Chem. 2012. PMID: 22497421 Free PMC article.

7

A critical assessment of docking programs and scoring functions.

Warren GL, Andrews CW, Capelli AM, Clarke B, LaLonde J, Lambert MH, Lindvall M, Nevins N, Semus SF, Senger S, Tedesco G, Wall ID, Woolven JM, Peishoff CE, Head MS. Warren GL, et al. Among authors: lalonde j. J Med Chem. 2006 Oct 5;49(20):5912-31. doi: 10.1021/jm050362n. J Med Chem. 2006. PMID: 17004707

8

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.

Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB 3rd. Lalonde JM, et al. Bioorg Med Chem. 2011 Jan 1;19(1):91-101. doi: 10.1016/j.bmc.2010.11.049. Epub 2010 Nov 26. Bioorg Med Chem. 2011. PMID: 21169023 Free PMC article.

9

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

Kumar S, Malachowski WP, DuHadaway JB, LaLonde JM, Carroll PJ, Jaller D, Metz R, Prendergast GC, Muller AJ. Kumar S, et al. Among authors: lalonde jm. J Med Chem. 2008 Mar 27;51(6):1706-18. doi: 10.1021/jm7014155. Epub 2008 Mar 5. J Med Chem. 2008. PMID: 18318466 Free PMC article.

10

O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.

Malachowski WP, Winters M, DuHadaway JB, Lewis-Ballester A, Badir S, Wai J, Rahman M, Sheikh E, LaLonde JM, Yeh SR, Prendergast GC, Muller AJ. Malachowski WP, et al. Among authors: lalonde jm. Eur J Med Chem. 2016 Jan 27;108:564-576. doi: 10.1016/j.ejmech.2015.12.028. Epub 2015 Dec 17. Eur J Med Chem. 2016. PMID: 26717206 Free PMC article.

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