Lewis C - Search Results

1

Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL. Qiu X, et al. Among authors: lewis c. Protein Sci. 2001 Oct;10(10):2008-16. doi: 10.1110/ps.18001. Protein Sci. 2001. PMID: 11567092 Free PMC article.

2

Structural variation and inhibitor binding in polypeptide deformylase from four different bacterial species.

Smith KJ, Petit CM, Aubart K, Smyth M, McManus E, Jones J, Fosberry A, Lewis C, Lonetto M, Christensen SB. Smith KJ, et al. Among authors: lewis c. Protein Sci. 2003 Feb;12(2):349-60. doi: 10.1110/ps.0229303. Protein Sci. 2003. PMID: 12538898 Free PMC article.

3

Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.

Concha NO, Janson CA, Rowling P, Pearson S, Cheever CA, Clarke BP, Lewis C, Galleni M, Frère JM, Payne DJ, Bateson JH, Abdel-Meguid SS. Concha NO, et al. Among authors: lewis c. Biochemistry. 2000 Apr 18;39(15):4288-98. doi: 10.1021/bi992569m. Biochemistry. 2000. PMID: 10757977

4

Type IIA topoisomerase inhibition by a new class of antibacterial agents.

Bax BD, Chan PF, Eggleston DS, Fosberry A, Gentry DR, Gorrec F, Giordano I, Hann MM, Hennessy A, Hibbs M, Huang J, Jones E, Jones J, Brown KK, Lewis CJ, May EW, Saunders MR, Singh O, Spitzfaden CE, Shen C, Shillings A, Theobald AJ, Wohlkonig A, Pearson ND, Gwynn MN. Bax BD, et al. Among authors: lewis cj. Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4. Nature. 2010. PMID: 20686482

5

A method for identification of inhibitors of the phosphorylation reactions of bacterial response regulator proteins using (31)P nuclear magnetic resonance spectroscopy.

Hubbard JA, MacLachlan LK, Johnson P, Findlow SC, Ladds JC, Lewis CJ, Carter PS, Jones JJ, Fosberry AP. Hubbard JA, et al. Among authors: lewis cj. Anal Biochem. 2001 Dec 1;299(1):31-6. doi: 10.1006/abio.2001.5365. Anal Biochem. 2001. PMID: 11726181

6

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD. Bax B, et al. Among authors: lewis c. Structure. 2001 Dec;9(12):1143-52. doi: 10.1016/s0969-2126(01)00679-7. Structure. 2001. PMID: 11738041 Free article.

7

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

Smith KJ, Carter PS, Bridges A, Horrocks P, Lewis C, Pettman G, Clarke A, Brown M, Hughes J, Wilkinson M, Bax B, Reith A. Smith KJ, et al. Among authors: lewis c. Structure. 2004 Jun;12(6):1067-77. doi: 10.1016/j.str.2004.02.040. Structure. 2004. PMID: 15274926 Free article.

8

Crystal structure of human cytochrome P450 2D6.

Rowland P, Blaney FE, Smyth MG, Jones JJ, Leydon VR, Oxbrow AK, Lewis CJ, Tennant MG, Modi S, Eggleston DS, Chenery RJ, Bridges AM. Rowland P, et al. J Biol Chem. 2006 Mar 17;281(11):7614-22. doi: 10.1074/jbc.M511232200. Epub 2005 Dec 13. J Biol Chem. 2006. PMID: 16352597 Free article.

9

Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1.

Islam T, Nunna V, Liyanarachchi DP, Melton D, Lewis CD, Gates KS. Islam T, et al. Among authors: lewis cd. Chem Res Toxicol. 2024 Dec 24. doi: 10.1021/acs.chemrestox.4c00445. Online ahead of print. Chem Res Toxicol. 2024. PMID: 39718352

10

Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs.

Lewis CJT, Xie LH, Bhandarkar SM, Jin D, Abdallah K, Draycott AS, Chen Y, Thoreen CC, Gilbert WV. Lewis CJT, et al. Mol Cell. 2024 Dec 12:S1097-2765(24)00955-9. doi: 10.1016/j.molcel.2024.11.030. Online ahead of print. Mol Cell. 2024. PMID: 39706187

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