Smith GC - Search Results

1

Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

Stockley M, Clegg W, Fontana G, Golding BT, Martin N, Rigoreau LJ, Smith GC, Griffin RJ. Stockley M, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2837-41. doi: 10.1016/s0960-894x(01)00537-6. Bioorg Med Chem Lett. 2001. PMID: 11597411

2

A FlashPlate assay for the identification of PARP-1 inhibitors.

Dillon KJ, Smith GC, Martin NM. Dillon KJ, et al. Among authors: smith gc. J Biomol Screen. 2003 Jun;8(3):347-52. doi: 10.1177/1087057103008003013. J Biomol Screen. 2003. PMID: 12857389

3

2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).

Hollick JJ, Golding BT, Hardcastle IR, Martin N, Richardson C, Rigoreau LJ, Smith GC, Griffin RJ. Hollick JJ, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3083-6. doi: 10.1016/s0960-894x(03)00652-8. Bioorg Med Chem Lett. 2003. PMID: 12941339

4

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Veuger SJ, et al. Among authors: smith gc. Cancer Res. 2003 Sep 15;63(18):6008-15. Cancer Res. 2003. PMID: 14522929

5

Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

Veuger SJ, Curtin NJ, Smith GC, Durkacz BW. Veuger SJ, et al. Among authors: smith gc. Oncogene. 2004 Sep 23;23(44):7322-9. doi: 10.1038/sj.onc.1207984. Oncogene. 2004. PMID: 15286704

6

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.

Leahy JJ, Golding BT, Griffin RJ, Hardcastle IR, Richardson C, Rigoreau L, Smith GC. Leahy JJ, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7. doi: 10.1016/j.bmcl.2004.09.060. Bioorg Med Chem Lett. 2004. PMID: 15546735

7

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC. Hickson I, et al. Among authors: smith gc. Cancer Res. 2004 Dec 15;64(24):9152-9. doi: 10.1158/0008-5472.CAN-04-2727. Cancer Res. 2004. PMID: 15604286

8

Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

Griffin RJ, Fontana G, Golding BT, Guiard S, Hardcastle IR, Leahy JJ, Martin N, Richardson C, Rigoreau L, Stockley M, Smith GC. Griffin RJ, et al. Among authors: smith gc. J Med Chem. 2005 Jan 27;48(2):569-85. doi: 10.1021/jm049526a. J Med Chem. 2005. PMID: 15658870

9

Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase.

Loh VM Jr, Cockcroft XL, Dillon KJ, Dixon L, Drzewiecki J, Eversley PJ, Gomez S, Hoare J, Kerrigan F, Matthews IT, Menear KA, Martin NM, Newton RF, Paul J, Smith GC, Vile J, Whittle AJ. Loh VM Jr, et al. Among authors: smith gc. Bioorg Med Chem Lett. 2005 May 2;15(9):2235-8. doi: 10.1016/j.bmcl.2005.03.026. Bioorg Med Chem Lett. 2005. PMID: 15837300

10

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026.

Nutley BP, Smith NF, Hayes A, Kelland LR, Brunton L, Golding BT, Smith GC, Martin NM, Workman P, Raynaud FI. Nutley BP, et al. Among authors: smith gc, smith nf. Br J Cancer. 2005 Oct 31;93(9):1011-8. doi: 10.1038/sj.bjc.6602823. Br J Cancer. 2005. PMID: 16249792 Free PMC article.

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