Froestl W - Search Results

1

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K. Urwyler S, et al. Among authors: froestl w. Mol Pharmacol. 2001 Nov;60(5):963-71. Mol Pharmacol. 2001. PMID: 11641424

2

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K. Urwyler S, et al. Among authors: froestl w. J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. doi: 10.1124/jpet.103.053074. Epub 2003 Sep 3. J Pharmacol Exp Ther. 2003. PMID: 12954816

3

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.

Kaupmann K, Schuler V, Mosbacher J, Bischoff S, Bittiger H, Heid J, Froestl W, Leonhard S, Pfaff T, Karschin A, Bettler B. Kaupmann K, et al. Among authors: froestl w. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14991-6. doi: 10.1073/pnas.95.25.14991. Proc Natl Acad Sci U S A. 1998. PMID: 9844003 Free PMC article.

4

The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

Malitschek B, Schweizer C, Keir M, Heid J, Froestl W, Mosbacher J, Kuhn R, Henley J, Joly C, Pin JP, Kaupmann K, Bettler B. Malitschek B, et al. Among authors: froestl w. Mol Pharmacol. 1999 Aug;56(2):448-54. doi: 10.1124/mol.56.2.448. Mol Pharmacol. 1999. PMID: 10419566

5

Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.

Lingenhoehl K, Brom R, Heid J, Beck P, Froestl W, Kaupmann K, Bettler B, Mosbacher J. Lingenhoehl K, et al. Among authors: froestl w. Neuropharmacology. 1999 Nov;38(11):1667-73. doi: 10.1016/s0028-3908(99)00131-8. Neuropharmacology. 1999. PMID: 10587082

6

Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.

Galvez T, Urwyler S, Prézeau L, Mosbacher J, Joly C, Malitschek B, Heid J, Brabet I, Froestl W, Bettler B, Kaupmann K, Pin JP. Galvez T, et al. Among authors: froestl w. Mol Pharmacol. 2000 Mar;57(3):419-26. doi: 10.1124/mol.57.3.419. Mol Pharmacol. 2000. PMID: 10692480

7

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Guery S, Floersheim P, Kaupmann K, Froestl W. Guery S, et al. Among authors: froestl w. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6206-11. doi: 10.1016/j.bmcl.2007.09.023. Epub 2007 Sep 8. Bioorg Med Chem Lett. 2007. PMID: 17884493 Free PMC article.

8

Ligands for expression cloning and isolation of GABA(B) receptors.

Froestl W, Bettler B, Bittiger H, Heid J, Kaupmann K, Mickel SJ, Strub D. Froestl W, et al. Farmaco. 2003 Mar;58(3):173-83. doi: 10.1016/s0014-827x(03)00018-1. Farmaco. 2003. PMID: 12620413 Review.

9

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.

Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Kaupmann K, et al. Among authors: froestl w. Eur J Neurosci. 2003 Nov;18(10):2722-30. doi: 10.1111/j.1460-9568.2003.03013.x. Eur J Neurosci. 2003. PMID: 14656321

10

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. Cryan JF, et al. Among authors: froestl w. J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. doi: 10.1124/jpet.104.066753. Epub 2004 Apr 27. J Pharmacol Exp Ther. 2004. PMID: 15113848

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