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Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives.
Ranise A, Spallarossa A, Schenone S, Bruno O, Bondavalli F, Vargiu L, Marceddu T, Mura M, La Colla P, Pani A. Ranise A, et al. Among authors: la colla p. J Med Chem. 2003 Feb 27;46(5):768-81. doi: 10.1021/jm0209984. J Med Chem. 2003. PMID: 12593657
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R. Mai A, et al. Among authors: la colla m, la colla p. J Med Chem. 2001 Aug 2;44(16):2544-54. doi: 10.1021/jm010853h. J Med Chem. 2001. PMID: 11472208
Pyrazole related nucleosides 5. Synthesis and biological activity of 2'-deoxy-2',3'-dideoxy- and acyclo-analogues of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR).
Manfredini S, Baraldi PG, Bazzanini R, Durini E, Vertuani S, Pani A, Marceddu T, Demontis F, Vargiu L, La Colla P. Manfredini S, et al. Among authors: la colla p. Nucleosides Nucleotides Nucleic Acids. 2000 Apr;19(4):705-22. doi: 10.1080/15257770008035019. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 10960030
Targeting HIV: old and new players.
Pani A, Loi AG, Mura M, Marceddu T, La Colla P, Marongiu ME. Pani A, et al. Among authors: la colla p. Curr Drug Targets Infect Disord. 2002 Mar;2(1):17-32. doi: 10.2174/1568005024605873. Curr Drug Targets Infect Disord. 2002. PMID: 12462150 Review.
Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant.
Ragno R, Mai A, Sbardella G, Artico M, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, La Colla P. Ragno R, et al. Among authors: la colla p. J Med Chem. 2004 Feb 12;47(4):928-34. doi: 10.1021/jm0309856. J Med Chem. 2004. PMID: 14761194
207 results