Janc J - Search Results

1

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.

Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Katz BA, et al. Among authors: janc j. Chem Biol. 2001 Nov;8(11):1107-21. doi: 10.1016/s1074-5521(01)00084-9. Chem Biol. 2001. PMID: 11731301

2

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW. Katz BA, et al. Among authors: janc jw. J Mol Biol. 2003 May 23;329(1):93-120. doi: 10.1016/s0022-2836(03)00399-1. J Mol Biol. 2003. PMID: 12742021

3

Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).

Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Katz BA, et al. Among authors: janc jw. J Mol Biol. 2004 Nov 19;344(2):527-47. doi: 10.1016/j.jmb.2004.09.032. J Mol Biol. 2004. PMID: 15522303

4

Contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors.

Katz BA, Spencer JR, Elrod K, Luong C, Mackman RL, Rice M, Sprengeler PA, Allen D, Janc J. Katz BA, et al. Among authors: janc j. J Am Chem Soc. 2002 Oct 2;124(39):11657-68. doi: 10.1021/ja020082m. J Am Chem Soc. 2002. PMID: 12296731

5

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.

Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. Katz BA, et al. Among authors: janc j. J Mol Biol. 2001 Apr 13;307(5):1451-86. doi: 10.1006/jmbi.2001.4516. J Mol Biol. 2001. PMID: 11292354

6

A novel approach to serine protease inhibition: kinetic characterization of inhibitors whose potencies and selectivities are dramatically enhanced by Zinc(II).

Janc JW, Clark JM, Warne RL, Elrod KC, Katz BA, Moore WR. Janc JW, et al. Biochemistry. 2000 Apr 25;39(16):4792-800. doi: 10.1021/bi992182j. Biochemistry. 2000. PMID: 10769136

7

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease.

Sperandio D, Gangloff AR, Litvak J, Goldsmith R, Hataye JM, Wang VR, Shelton EJ, Elrod K, Janc JW, Clark JM, Rice K, Weinheimer S, Yeung KS, Meanwell NA, Hernandez D, Staab AJ, Venables BL, Spencer JR. Sperandio D, et al. Among authors: janc jw. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3129-33. doi: 10.1016/s0960-894x(02)00680-7. Bioorg Med Chem Lett. 2002. PMID: 12372517

8

Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation.

Young WB, Sprengeler P, Shrader WD, Li Y, Rai R, Verner E, Jenkins T, Fatheree P, Kolesnikov A, Janc JW, Cregar L, Elrod K, Katz B. Young WB, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):710-3. doi: 10.1016/j.bmcl.2005.10.023. Epub 2005 Oct 27. Bioorg Med Chem Lett. 2006. PMID: 16257204

9

Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.

Young WB, Mordenti J, Torkelson S, Shrader WD, Kolesnikov A, Rai R, Liu L, Hu H, Leahy EM, Green MJ, Sprengeler PA, Katz BA, Yu C, Janc JW, Elrod KC, Marzec UM, Hanson SR. Young WB, et al. Among authors: janc jw. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2037-41. doi: 10.1016/j.bmcl.2005.12.059. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16412633

10

Factor VIIa inhibitors: gaining selectivity within the trypsin family.

Shrader WD, Kolesnikov A, Burgess-Henry J, Rai R, Hendrix J, Hu H, Torkelson S, Ton T, Young WB, Katz BA, Yu C, Tang J, Cabuslay R, Sanford E, Janc JW, Sprengeler PA. Shrader WD, et al. Among authors: janc jw. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1596-600. doi: 10.1016/j.bmcl.2005.12.040. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413783

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