Loi CM - Search Results

1

In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.

Lin YS, Lockwood GF, Graham MA, Brian WR, Loi CM, Dobrinska MR, Shen DD, Watkins PB, Wilkinson GR, Kharasch ED, Thummel KE. Lin YS, et al. Among authors: loi cm. Pharmacogenetics. 2001 Dec;11(9):781-91. doi: 10.1097/00008571-200112000-00006. Pharmacogenetics. 2001. PMID: 11740342

2

Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.

Brian W, Tremaine LM, Arefayene M, de Kanter R, Evers R, Guo Y, Kalabus J, Lin W, Loi CM, Xiao G. Brian W, et al. Among authors: loi cm. Pharmacogenomics. 2016 Apr;17(6):615-31. doi: 10.2217/pgs.16.9. Epub 2016 Apr 5. Pharmacogenomics. 2016. PMID: 27045656 Review.

3

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: loi cm. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377

4

How current understanding of clearance mechanisms and pharmacodynamics of therapeutic proteins can be applied for evaluation of their drug-drug interaction potential.

Kraynov E, Martin SW, Hurst S, Fahmi OA, Dowty M, Cronenberger C, Loi CM, Kuang B, Fields O, Fountain S, Awwad M, Wang D. Kraynov E, et al. Among authors: loi cm. Drug Metab Dispos. 2011 Oct;39(10):1779-83. doi: 10.1124/dmd.111.040808. Epub 2011 Jul 18. Drug Metab Dispos. 2011. PMID: 21768274 Review.

5

Which metabolites circulate?

Loi CM, Smith DA, Dalvie D. Loi CM, et al. Drug Metab Dispos. 2013 May;41(5):933-51. doi: 10.1124/dmd.112.050278. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454828

6

Physiologically Based Pharmacokinetic Modeling of Palbociclib.

Yu Y, Loi CM, Hoffman J, Wang D. Yu Y, et al. Among authors: loi cm. J Clin Pharmacol. 2017 Feb;57(2):173-184. doi: 10.1002/jcph.792. Epub 2016 Aug 22. J Clin Pharmacol. 2017. PMID: 27402157 Clinical Trial.

7

Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions.

Ono C, Hsyu PH, Abbas R, Loi CM, Yamazaki S. Ono C, et al. Among authors: loi cm. Drug Metab Dispos. 2017 Apr;45(4):390-398. doi: 10.1124/dmd.116.074450. Epub 2017 Feb 6. Drug Metab Dispos. 2017. PMID: 28167538

8

Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein.

Yamazaki S, Loi CM, Kimoto E, Costales C, Varma MV. Yamazaki S, et al. Among authors: loi cm. Drug Metab Dispos. 2018 Aug;46(8):1200-1211. doi: 10.1124/dmd.118.080424. Epub 2018 May 8. Drug Metab Dispos. 2018. PMID: 29739809

9

Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans.

Hurst S, Loi CM, Brodfuehrer J, El-Kattan A. Hurst S, et al. Among authors: loi cm. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):469-89. doi: 10.1517/17425225.3.4.469. Expert Opin Drug Metab Toxicol. 2007. PMID: 17696800 Review.

10

Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences.

Dalvie D, Zhang C, Chen W, Smolarek T, Obach RS, Loi CM. Dalvie D, et al. Among authors: loi cm. Drug Metab Dispos. 2010 Apr;38(4):641-54. doi: 10.1124/dmd.109.030783. Epub 2009 Dec 29. Drug Metab Dispos. 2010. PMID: 20040581

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