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Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.
J Med Chem. 2002 Jan 3;45(1):1-18. doi: 10.1021/jm0102203.
J Med Chem. 2002.
PMID: 11754575
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.
Borthwick AD, Angier SJ, Crame AJ, Exall AM, Haley TM, Hart GJ, Mason AM, Pennell AM, Weingarten GG.
Borthwick AD, et al. Among authors: crame aj.
J Med Chem. 2000 Nov 16;43(23):4452-64. doi: 10.1021/jm000078q.
J Med Chem. 2000.
PMID: 11087570
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Synthesis of benzodioxinopyrroles as selective alpha 2-adrenoceptor antagonists.
Kitchin J, Borthwick AD, Brodie AC, Cherry PC, Crame AJ, Pipe AJ, Procopiou PA, Seaman MA, Turnbull JP.
Kitchin J, et al. Among authors: crame aj.
Bioorg Med Chem. 1995 Dec;3(12):1595-603. doi: 10.1016/0968-0896(95)00143-3.
Bioorg Med Chem. 1995.
PMID: 8770384
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Structure-activity relationships of some synthetic atrial natriuretic peptide analogues.
Crame AJ, Dodds MG, Dolamore PG, Kitchin J, Louttit JB, Pipe AJ, Ross BC, Seale PW, Ward P, Wise H.
Crame AJ, et al.
Biochem Soc Trans. 1990 Dec;18(6):1320-1. doi: 10.1042/bst0181320.
Biochem Soc Trans. 1990.
PMID: 2150956
No abstract available.
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