Vasquez G - Search Results

1

Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides.

Prakash TP, Kawasaki AM, Fraser AS, Vasquez G, Manoharan M. Prakash TP, et al. Among authors: vasquez g. J Org Chem. 2002 Jan 25;67(2):357-69. doi: 10.1021/jo0103975. J Org Chem. 2002. PMID: 11798305

2

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. Prakash TP, et al. Among authors: vasquez g. Org Lett. 2000 Dec 14;2(25):3995-8. doi: 10.1021/ol006555g. Org Lett. 2000. PMID: 11112626

3

Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo.

Shen L, Siwkowski A, Wancewicz EV, Lesnik E, Butler M, Witchell D, Vasquez G, Ross B, Acevedo O, Inamati G, Sasmor H, Manoharan M, Monia BP. Shen L, et al. Among authors: vasquez g. Antisense Nucleic Acid Drug Dev. 2003;13(3):129-42. doi: 10.1089/108729003768247592. Antisense Nucleic Acid Drug Dev. 2003. PMID: 12954113

4

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Kinberger G, Migawa MT, Gaus H, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. Nucleic Acids Symp Ser (Oxf). 2008;(52):553-4. doi: 10.1093/nass/nrn280. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776499

5

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Med Chem. 2009 Jan 8;52(1):10-3. doi: 10.1021/jm801294h. J Med Chem. 2009. PMID: 19086780

6

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

7

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.

Seth PP, Allerson CR, Siwkowski A, Vasquez G, Berdeja A, Migawa MT, Gaus H, Prakash TP, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Med Chem. 2010 Dec 9;53(23):8309-18. doi: 10.1021/jm101207e. Epub 2010 Nov 8. J Med Chem. 2010. PMID: 21058707

8

Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA).

Migawa MT, Prakash TP, Vasquez G, Seth PP, Swayze EE. Migawa MT, et al. Among authors: vasquez g. Org Lett. 2013 Sep 6;15(17):4316-9. doi: 10.1021/ol401730d. Epub 2013 Aug 13. Org Lett. 2013. PMID: 23937264

9

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.

Wan WB, Migawa MT, Vasquez G, Murray HM, Nichols JG, Gaus H, Berdeja A, Lee S, Hart CE, Lima WF, Swayze EE, Seth PP. Wan WB, et al. Among authors: vasquez g. Nucleic Acids Res. 2014 Dec 16;42(22):13456-68. doi: 10.1093/nar/gku1115. Epub 2014 Nov 14. Nucleic Acids Res. 2014. PMID: 25398895 Free PMC article.

10

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.

Østergaard ME, Yu J, Kinberger GA, Wan WB, Migawa MT, Vasquez G, Schmidt K, Gaus HJ, Murray HM, Low A, Swayze EE, Prakash TP, Seth PP. Østergaard ME, et al. Among authors: vasquez g. Bioconjug Chem. 2015 Aug 19;26(8):1451-5. doi: 10.1021/acs.bioconjchem.5b00265. Epub 2015 Jun 10. Bioconjug Chem. 2015. PMID: 26011654

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