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Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome.
Kyng KJ, May A, Stevnsner T, Becker KG, Kølvrå S, Bohr VA. Kyng KJ, et al. Among authors: may a. Oncogene. 2005 Jul 28;24(32):5026-42. doi: 10.1038/sj.onc.1208692. Oncogene. 2005. PMID: 15897889
We examined transcription in cells from young and old individuals and from patients with Werner syndrome (WS), a segmental progeroid condition with a high incidence of cancer, and found various age-associated transcriptional changes depending upon the type of cellul …
We examined transcription in cells from young and old individuals and from patients with Werner syndrome (WS), a segmental progeroid …
DNA repair of pyrimidine dimers and 6-4 photoproducts in the ribosomal DNA.
Balajee AS, May A, Bohr VA. Balajee AS, et al. Among authors: may a. Nucleic Acids Res. 1999 Jun 15;27(12):2511-20. doi: 10.1093/nar/27.12.2511. Nucleic Acids Res. 1999. PMID: 10352180 Free PMC article.
The nucleolus is a unique structural component of interphase nuclei where the ribosomal genes, trans-cribed by RNA polymerase I (RNA pol I), are organized. ...This lack of enrichment of NER factors in the nucleolus may be responsible for the inefficient repair of ph …
The nucleolus is a unique structural component of interphase nuclei where the ribosomal genes, trans-cribed by RNA polymerase I (RNA …
Gene expression profiling in Werner syndrome closely resembles that of normal aging.
Kyng KJ, May A, Kølvraa S, Bohr VA. Kyng KJ, et al. Among authors: may a. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12259-64. doi: 10.1073/pnas.2130723100. Epub 2003 Oct 3. Proc Natl Acad Sci U S A. 2003. PMID: 14527998 Free PMC article.
Werner syndrome (WS) is a premature aging disorder, displaying defects in DNA replication, recombination, repair, and transcription. It has been hypothesized that several WS phenotypes are secondary consequences of aberrant gene expression and that a transcription d …
Werner syndrome (WS) is a premature aging disorder, displaying defects in DNA replication, recombination, repair, and transcription. …
2,636 results