Kimura A - Search Results

1

A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease.

Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A. Shirai N, et al. Among authors: kimura a. Cardiovasc Res. 2002 Feb 1;53(2):348-54. doi: 10.1016/s0008-6363(01)00494-1. Cardiovasc Res. 2002. PMID: 11827685

2

Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.

Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A. Sasaki K, et al. Among authors: kimura a. Mol Pharmacol. 2004 Aug;66(2):330-6. doi: 10.1124/mol.66.2.330. Mol Pharmacol. 2004. PMID: 15266024

3

Spontaneous T wave alternans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing.

Nishizaki M, Fujii H, Sakurada H, Kimura A, Hiraoka M. Nishizaki M, et al. Among authors: kimura a. J Cardiovasc Electrophysiol. 2005 Feb;16(2):217-20. doi: 10.1046/j.1540-8167.2004.40411.x. J Cardiovasc Electrophysiol. 2005. PMID: 15720462

4

A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5.

Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. Ishikawa T, et al. Among authors: kimura a. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1098-107. doi: 10.1161/CIRCEP.111.969972. Epub 2012 Oct 12. Circ Arrhythm Electrophysiol. 2012. PMID: 23064965

5

Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5.

Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Ishikawa T, et al. Among authors: kimura a. Circ J. 2013;77(4):959-67. doi: 10.1253/circj.cj-12-0995. Epub 2012 Dec 21. Circ J. 2013. PMID: 23257389 Free article. Clinical Trial.

6

Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation.

Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M. Sasano T, et al. Among authors: kimura a. J Mol Cell Cardiol. 2004 Dec;37(6):1205-11. doi: 10.1016/j.yjmcc.2004.09.010. J Mol Cell Cardiol. 2004. PMID: 15572050

7

Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.

Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M. Aizawa Y, et al. Among authors: kimura a. FEBS Lett. 2004 Sep 10;574(1-3):145-50. doi: 10.1016/j.febslet.2004.08.018. FEBS Lett. 2004. PMID: 15358555 Free article.

8

Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome.

Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A. Sato A, et al. Among authors: kimura a. J Biol Chem. 2009 Dec 11;284(50):35122-33. doi: 10.1074/jbc.M109.017293. Epub 2009 Oct 13. J Biol Chem. 2009. PMID: 19825999 Free PMC article.

9

Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias.

Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N, Furukawa T. Koizumi A, et al. Among authors: kimura a, kimura w. Eur Heart J. 2016 May 7;37(18):1469-75. doi: 10.1093/eurheartj/ehv449. Epub 2015 Oct 1. Eur Heart J. 2016. PMID: 26429810 Free PMC article.

10

Role of HCN4 channel in preventing ventricular arrhythmia.

Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A. Ueda K, et al. Among authors: kimura a. J Hum Genet. 2009 Feb;54(2):115-21. doi: 10.1038/jhg.2008.16. Epub 2009 Jan 23. J Hum Genet. 2009. PMID: 19165230

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