Hallam C - Search Results

1

Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.

Connolly S, Bennion C, Botterell S, Croshaw PJ, Hallam C, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Smith GM, Stein L, Walters I, Wells E, Withnall WJ. Connolly S, et al. Among authors: hallam c. J Med Chem. 2002 Mar 14;45(6):1348-62. doi: 10.1021/jm011050x. J Med Chem. 2002. PMID: 11882004

2

Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex.

Bennion C, Connolly S, Gensmantel NP, Hallam C, Jackson CG, Primrose WU, Roberts GC, Robinson DH, Slaich PK. Bennion C, et al. Among authors: hallam c. J Med Chem. 1992 Aug 7;35(16):2939-51. doi: 10.1021/jm00094a003. J Med Chem. 1992. PMID: 1501221

3

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.

Beaton HG, Bennion C, Connolly S, Cook AR, Gensmantel NP, Hallam C, Hardy K, Hitchin B, Jackson CG, Robinson DH. Beaton HG, et al. Among authors: hallam c. J Med Chem. 1994 Mar 4;37(5):557-9. doi: 10.1021/jm00031a001. J Med Chem. 1994. PMID: 8126692 No abstract available.

4

(R)-2-(3-mercapto-2(S)-methyl-1-oxo-propoxy)-3-(methylthio)propanoic acid, the first ultra-short-acting angiotensin converting enzyme inhibitor.

Baxter AJ, Carr RD, Eyley SC, Fraser-Rae L, Hallam C, Harper ST, Hurved PA, King SJ, Meghani P. Baxter AJ, et al. Among authors: hallam c. J Med Chem. 1992 Oct 2;35(20):3718-20. doi: 10.1021/jm00098a019. J Med Chem. 1992. PMID: 1433185 No abstract available.

5

Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.

Currie S, Smith GL, Crichton CA, Jackson CG, Hallam C, Wakelam MJ. Currie S, et al. Among authors: hallam c. J Biol Chem. 1992 Mar 25;267(9):6056-62. J Biol Chem. 1992. PMID: 1532578 Free article.

6

Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.

Bonnert RV, Brown RC, Chapman D, Cheshire DR, Dixon J, Ince F, Kinchin EC, Lyons AJ, Davis AM, Hallam C, Harper ST, Unitt JF, Dougall IG, Jackson DM, McKechnie K, Young A, Simpson WT. Bonnert RV, et al. Among authors: hallam c. J Med Chem. 1998 Dec 3;41(25):4915-7. doi: 10.1021/jm980421f. J Med Chem. 1998. PMID: 9836607 No abstract available.

7

Enhancement of leukotriene C4 release from primate airway macrophages by cellular interactions.

Campbell AM, Harper ST, Hallam C, Wells E, Mann J, Robinson C. Campbell AM, et al. Among authors: hallam c. Br J Pharmacol. 1989 Oct;98(2):637-45. doi: 10.1111/j.1476-5381.1989.tb12638.x. Br J Pharmacol. 1989. PMID: 2819337 Free PMC article.

8

Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze.

Kaiser FC, Palmer GC, Wallace AV, Carr RD, Fraser-Rae L, Hallam C. Kaiser FC, et al. Among authors: hallam c. Neuroreport. 1992 Oct;3(10):922-4. doi: 10.1097/00001756-199210000-00026. Neuroreport. 1992. PMID: 1358253

9

FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor.

Blackham A, Griffiths RJ, Hallam C, Mann J, Mitchell PD, Norris AA, Simpson WT. Blackham A, et al. Among authors: hallam c. Agents Actions. 1990 Jun;30(3-4):432-42. doi: 10.1007/BF01966309. Agents Actions. 1990. PMID: 2117338

10

SARS-CoV-2 recombinant spike ferritin nanoparticle vaccine adjuvanted with Army Liposome Formulation containing monophosphoryl lipid A and QS-21: a phase 1, randomised, double-blind, placebo-controlled, first-in-human clinical trial.

Ober Shepherd BL, Scott PT, Hutter JN, Lee C, McCauley MD, Guzman I, Bryant C, McGuire S, Kennedy J, Chen WH, Hajduczki A, Mdluli T, Valencia-Ruiz A, Amare MF, Matyas GR, Rao M, Rolland M, Mascola JR, De Rosa SC, McElrath MJ, Montefiori DC, Serebryannyy L, McDermott AB, Peel SA, Collins ND, Joyce MG, Robb ML, Michael NL, Vasan S, Modjarrad K; EID-030 Study Group. Ober Shepherd BL, et al. Lancet Microbe. 2024 Jun;5(6):e581-e593. doi: 10.1016/S2666-5247(23)00410-X. Epub 2024 May 15. Lancet Microbe. 2024. PMID: 38761816 Free article. Clinical Trial.

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