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Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.
Urano W, Taniguchi A, Yamanaka H, Tanaka E, Nakajima H, Matsuda Y, Akama H, Kitamura Y, Kamatani N. Urano W, et al. Among authors: akama h. Pharmacogenetics. 2002 Apr;12(3):183-90. doi: 10.1097/00008571-200204000-00002. Pharmacogenetics. 2002. PMID: 11927833
[Pharmacogenomics of the immunosuppressive agents].
Taniguchi A, Urano W, Tanaka E, Kitamura Y, Saito M, Akama H, Yamanak H, Saito T, Kamatani N. Taniguchi A, et al. Among authors: akama h. Nihon Rinsho Meneki Gakkai Kaishi. 2002 Feb;25(1):105-9. Nihon Rinsho Meneki Gakkai Kaishi. 2002. PMID: 11963167 Review. Japanese. No abstract available.
Adalimumab, a human anti-TNF monoclonal antibody, outcome study for the prevention of joint damage in Japanese patients with early rheumatoid arthritis: the HOPEFUL 1 study.
Takeuchi T, Yamanaka H, Ishiguro N, Miyasaka N, Mukai M, Matsubara T, Uchida S, Akama H, Kupper H, Arora V, Tanaka Y. Takeuchi T, et al. Among authors: akama h. Ann Rheum Dis. 2014 Mar;73(3):536-43. doi: 10.1136/annrheumdis-2012-202433. Epub 2013 Jan 11. Ann Rheum Dis. 2014. PMID: 23316080 Free PMC article. Clinical Trial.
Recovery of clinical but not radiographic outcomes by the delayed addition of adalimumab to methotrexate-treated Japanese patients with early rheumatoid arthritis: 52-week results of the HOPEFUL-1 trial.
Yamanaka H, Ishiguro N, Takeuchi T, Miyasaka N, Mukai M, Matsubara T, Uchida S, Akama H, Kupper H, Arora V, Tanaka Y. Yamanaka H, et al. Among authors: akama h. Rheumatology (Oxford). 2014 May;53(5):904-13. doi: 10.1093/rheumatology/ket465. Epub 2014 Jan 17. Rheumatology (Oxford). 2014. PMID: 24441150 Free PMC article. Clinical Trial.
124 results