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118 results

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Page 1
Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.
Aslanian R, Mutahi MW, Shih NY, McCormick KD, Piwinski JJ, Ting PC, Albanese MM, Berlin MY, Zhu X, Wong SC, Rosenblum SB, Jiang Y, West R, She S, Williams SM, Bryant M, Hey JA. Aslanian R, et al. Among authors: shih ny. Bioorg Med Chem Lett. 2002 Mar 25;12(6):937-41. doi: 10.1016/s0960-894x(02)00055-0. Bioorg Med Chem Lett. 2002. PMID: 11958998
Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).
McLeod RL, Rizzo CA, West RE Jr, Aslanian R, McCormick K, Bryant M, Hsieh Y, Korfmacher W, Mingo GG, Varty L, Williams SM, Shih NY, Egan RW, Hey JA. McLeod RL, et al. Among authors: shih ny. J Pharmacol Exp Ther. 2003 Jun;305(3):1037-44. doi: 10.1124/jpet.103.049254. Epub 2003 Mar 20. J Pharmacol Exp Ther. 2003. PMID: 12649305
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
Ting PC, Lee JF, Wu J, Umland SP, Aslanian R, Cao J, Dong Y, Garlisi CG, Gilbert EJ, Huang Y, Jakway J, Kelly J, Liu Z, McCombie S, Shah H, Tian F, Wan Y, Shih NY. Ting PC, et al. Among authors: shih ny. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1375-8. doi: 10.1016/j.bmcl.2005.01.016. Bioorg Med Chem Lett. 2005. PMID: 15713390
Cyclic urea derivatives as potent NK1 selective antagonists.
Shue HJ, Chen X, Shih NY, Blythin DJ, Paliwal S, Lin L, Gu D, Schwerdt JH, Shah S, Reichard GA, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Liu F, Nomeir AA, Morgan CA, Varty GB. Shue HJ, et al. Among authors: shih ny. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3896-9. doi: 10.1016/j.bmcl.2005.05.111. Bioorg Med Chem Lett. 2005. PMID: 16019209
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Vaccaro WD, Sher R, Berlin M, Shih NY, Aslanian R, Schwerdt JH, McCormick KD, Piwinski JJ, West RE Jr, Anthes JC, Williams SM, Wu RL, She HS, Rivelli MA, Mutter JC, Corboz MR, Hey JA, Favreau L. Vaccaro WD, et al. Among authors: shih ny. Bioorg Med Chem Lett. 2006 Jan 15;16(2):395-9. doi: 10.1016/j.bmcl.2005.09.076. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246552
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Berlin M, Ting PC, Vaccaro WD, Aslanian R, McCormick KD, Lee JF, Albanese MM, Mutahi MW, Piwinski JJ, Shih NY, Duguma L, Solomon DM, Zhou W, Sher R, Favreau L, Bryant M, Korfmacher WA, Nardo C, West RE Jr, Anthes JC, Williams SM, Wu RL, Susan She H, Rivelli MA, Corboz MR, Hey JA. Berlin M, et al. Among authors: shih ny. Bioorg Med Chem Lett. 2006 Feb 15;16(4):989-94. doi: 10.1016/j.bmcl.2005.10.087. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16297617
III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold.
Kim SH, Anilkumar GN, Zawacki LG, Zeng Q, Yang DY, Shao Y, Dong G, Xu X, Yu W, Jiang Y, Jenh CH, Hall JW 3rd, Carroll CD, Hobbs DW, Baldwin JJ, McGuinness BF, Rosenblum SB, Kozlowski JA, Shankar BB, Shih NY. Kim SH, et al. Among authors: shih ny. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6982-6. doi: 10.1016/j.bmcl.2011.09.120. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22018463
118 results