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Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.
Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC. Whitten AE, et al. Among authors: margetts mb. J Mol Biol. 2009 Dec 18;394(5):878-92. doi: 10.1016/j.jmb.2009.10.011. Epub 2009 Oct 14. J Mol Biol. 2009. PMID: 19835884
How insulin engages its primary binding site on the insulin receptor.
Menting JG, Whittaker J, Margetts MB, Whittaker LJ, Kong GK, Smith BJ, Watson CJ, Záková L, Kletvíková E, Jiráček J, Chan SJ, Steiner DF, Dodson GG, Brzozowski AM, Weiss MA, Ward CW, Lawrence MC. Menting JG, et al. Among authors: margetts mb. Nature. 2013 Jan 10;493(7431):241-5. doi: 10.1038/nature11781. Nature. 2013. PMID: 23302862 Free PMC article.
37 results