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Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.
Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y. Yamagata K, et al. Among authors: hanafusa t. Diabetes. 2002 Jan;51(1):114-23. doi: 10.2337/diabetes.51.1.114. Diabetes. 2002. PMID: 11756330
Interferon stimulated gene 15 has an anti-apoptotic effect on MIN6 cells.
Yoshikawa A, Imagawa A, Nakata S, Fukui K, Kuroda Y, Miyata Y, Sato Y, Hanafusa T, Matsuoka TA, Kaneto H, Iwahashi H, Shimomura I. Yoshikawa A, et al. Among authors: hanafusa t. Endocr J. 2014;61(9):883-90. doi: 10.1507/endocrj.ej14-0219. Epub 2014 Jul 15. Endocr J. 2014. PMID: 25031023 Free article.
Benefit of Early Add-on of Linagliptin to Insulin in Japanese Patients With Type 2 Diabetes Mellitus: Randomized-Controlled Open-Label Trial (TRUST2).
Katsuno T, Shiraiwa T, Iwasaki S, Park H, Watanabe N, Kaneko S, Terasaki J, Hanafusa T, Imagawa A, Shimomura I, Ikegami H, Koyama H, Namba M, Miyagawa JI; TRUST2 study group. Katsuno T, et al. Among authors: hanafusa t. Adv Ther. 2021 Mar;38(3):1514-1535. doi: 10.1007/s12325-021-01631-y. Epub 2021 Jan 28. Adv Ther. 2021. PMID: 33507500 Clinical Trial.
695 results